Drug-induced liver injury: Which Medications Cause It? (26,439 Reports Across 1,067 Drugs)
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Drug-induced liver injury has been reported as an adverse event with 1,067 different drugs in the FDA's FAERS database, with 26,439 total reports. 2,855 of these reports resulted in death.The drugs most commonly associated with Drug-induced liver injury are ACETAMINOPHEN, METHOTREXATE, and ADALIMUMAB.
26,439
Total Reports
1,067
Drugs Involved
2,855
Deaths
12,080
Hospitalizations
52.0 yrs
Average Patient Age
57.6% / 42.4%
Female / Male
Which Drugs Cause Drug-induced liver injury Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| ACETAMINOPHEN | 2,092 | 1.5% | 758 | 1,499 | 623 |
| METHOTREXATE | 1,807 | 0.7% | 535 | 813 | 470 |
| ADALIMUMAB | 1,400 | 0.3% | 549 | 664 | 458 |
| LEFLUNOMIDE | 1,084 | 1.9% | 509 | 661 | 502 |
| INFLIXIMAB | 1,051 | 0.8% | 532 | 620 | 447 |
| HYDROXYCHLOROQUINE | 1,037 | 1.6% | 502 | 599 | 425 |
| DICLOFENAC | 1,025 | 1.2% | 574 | 662 | 475 |
| ATORVASTATIN | 990 | 1.2% | 50 | 488 | 67 |
| TOCILIZUMAB | 968 | 1.0% | 569 | 629 | 457 |
| RITUXIMAB | 953 | 0.5% | 545 | 610 | 485 |
| PREDNISONE | 943 | 0.6% | 528 | 655 | 463 |
| ETANERCEPT | 921 | 0.3% | 463 | 510 | 386 |
| SULFASALAZINE | 886 | 2.2% | 463 | 530 | 402 |
| ABATACEPT | 873 | 0.8% | 424 | 517 | 396 |
| METHYLPREDNISOLONE | 866 | 1.4% | 446 | 547 | 355 |
| AZATHIOPRINE | 861 | 2.6% | 513 | 528 | 420 |
| CERTOLIZUMAB PEGOL | 813 | 0.8% | 530 | 531 | 445 |
| GOLIMUMAB | 771 | 1.1% | 503 | 483 | 416 |
| ISONIAZID | 766 | 10.1% | 180 | 244 | 36 |
| CETIRIZINE | 752 | 1.6% | 546 | 594 | 481 |