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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Drug use disorder: Which Medications Cause It? (7,003 Reports Across 218 Drugs)

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Drug use disorder has been reported as an adverse event with 218 different drugs in the FDA's FAERS database, with 7,003 total reports. 486 of these reports resulted in death.The drugs most commonly associated with Drug use disorder are PREGABALIN, TRAMADOL, and OXYCODONE.

7,003
Total Reports
218
Drugs Involved
486
Deaths
2,046
Hospitalizations
39.6 yrs
Average Patient Age
44.7% / 55.3%
Female / Male

Which Drugs Cause Drug use disorder Most Often?

Drug Reports % of Drug Reports Deaths Hosp. Life-Threat.
PREGABALIN 968 1.0% 8 382 53
TRAMADOL 913 1.2% 54 313 57
OXYCODONE 880 0.5% 67 140 12
COCAINE 848 6.0% 34 255 110
DIAZEPAM 832 2.2% 51 283 108
ALPRAZOLAM 759 1.6% 36 247 10
CANNABIS SATIVA SUBSP. INDICA TOP 744 8.6% 27 243 86
BUPRENORPHINE 481 0.6% 58 207 41
ZOLPIDEM 451 2.1% 3 109 14
CLONAZEPAM 450 1.1% 10 171 46
CODEINE 442 2.0% 11 33 14
FENTANYL 430 0.5% 55 183 35
ALCOHOL 378 1.7% 24 96 35
MORPHINE 375 0.3% 43 130 25
BROMAZEPAM 351 5.6% 26 137 25
OXAZEPAM 339 2.7% 3 122 36
TRAMADOL\TRAMADOL 320 8.1% 13 78 37
HYDROCODONE 283 0.6% 7 16 0
NALTREXONE 274 1.1% 11 33 0
ACETAMINOPHEN 268 0.2% 16 56 15

View all 218 drugs →

Top 3 Drugs Associated With Drug use disorder

968 reports
913 reports
880 reports

Related Side Effects

Drug ineffective (1,049,718) Off label use (762,782) Death (660,423) Fatigue (599,248) Nausea (562,301) Diarrhoea (491,550) Pain (471,975) Headache (460,069) Dyspnoea (409,496) Dizziness (352,922)