Drug withdrawal syndrome: Which Medications Cause It? (65,705 Reports Across 527 Drugs)
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Drug withdrawal syndrome has been reported as an adverse event with 527 different drugs in the FDA's FAERS database, with 65,705 total reports. 2,317 of these reports resulted in death.The drugs most commonly associated with Drug withdrawal syndrome are OXYCODONE, MORPHINE, and HYDROMORPHONE.
65,705
Total Reports
527
Drugs Involved
2,317
Deaths
7,353
Hospitalizations
46.1 yrs
Average Patient Age
47.2% / 52.8%
Female / Male
Which Drugs Cause Drug withdrawal syndrome Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| OXYCODONE | 36,595 | 19.2% | 1,859 | 1,220 | 114 |
| MORPHINE | 14,954 | 12.4% | 646 | 755 | 78 |
| HYDROMORPHONE | 14,834 | 17.8% | 679 | 676 | 73 |
| ACETAMINOPHEN\HYDROCODONE | 8,378 | 7.7% | 373 | 538 | 36 |
| BUPRENORPHINE | 7,149 | 8.7% | 275 | 568 | 64 |
| HYDROCODONE | 6,832 | 14.3% | 282 | 180 | 12 |
| DULOXETINE | 6,503 | 12.5% | 30 | 479 | 75 |
| ACETAMINOPHEN\OXYCODONE\OXYCODONE TEREPHTHALATE | 4,618 | 39.4% | 208 | 185 | 15 |
| ACETAMINOPHEN\OXYCODONE | 4,417 | 4.4% | 280 | 529 | 49 |
| FENTANYL | 3,206 | 3.4% | 151 | 564 | 78 |
| BUPRENORPHINE\NALOXONE | 3,167 | 14.6% | 41 | 519 | 62 |
| TRAMADOL | 2,943 | 3.9% | 167 | 502 | 62 |
| BACLOFEN | 2,284 | 8.9% | 52 | 1,070 | 144 |
| METHADONE | 2,127 | 8.1% | 82 | 350 | 36 |
| PREGABALIN | 1,487 | 1.5% | 10 | 370 | 24 |
| OXYMORPHONE | 859 | 2.3% | 28 | 62 | 8 |
| VENLAFAXINE | 844 | 1.8% | 19 | 170 | 50 |
| ALPRAZOLAM | 799 | 1.7% | 45 | 346 | 43 |
| DIAMORPHINE | 732 | 8.1% | 77 | 156 | 10 |
| CLONAZEPAM | 695 | 1.8% | 41 | 281 | 101 |