Epidermal necrosis: Which Medications Cause It? (653 Reports Across 84 Drugs)
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Epidermal necrosis has been reported as an adverse event with 84 different drugs in the FDA's FAERS database, with 653 total reports. 102 of these reports resulted in death.The drugs most commonly associated with Epidermal necrosis are METHOTREXATE, LAMOTRIGINE, and IBUPROFEN.
653
Total Reports
84
Drugs Involved
102
Deaths
404
Hospitalizations
52.9 yrs
Average Patient Age
57.2% / 42.8%
Female / Male
Which Drugs Cause Epidermal necrosis Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| METHOTREXATE | 198 | 0.1% | 49 | 124 | 83 |
| LAMOTRIGINE | 50 | 0.1% | 2 | 43 | 7 |
| IBUPROFEN | 41 | 0.1% | 8 | 38 | 8 |
| ACETAMINOPHEN | 38 | 0.0% | 2 | 32 | 2 |
| NAPROXEN | 35 | 0.1% | 0 | 30 | 0 |
| GABAPENTIN | 32 | 0.0% | 0 | 32 | 0 |
| ATORVASTATIN | 30 | 0.0% | 0 | 27 | 0 |
| PREGABALIN | 30 | 0.0% | 0 | 30 | 0 |
| BRINZOLAMIDE\TIMOLOL | 28 | 4.9% | 0 | 28 | 0 |
| AMOXICILLIN | 26 | 0.1% | 0 | 26 | 2 |
| CLONAZEPAM | 26 | 0.1% | 0 | 25 | 0 |
| CYCLOPHOSPHAMIDE | 26 | 0.0% | 3 | 18 | 1 |
| ESTRADIOL | 25 | 0.1% | 0 | 25 | 0 |
| CALCIUM | 24 | 0.2% | 0 | 24 | 0 |
| FOLIC ACID | 24 | 0.1% | 0 | 24 | 1 |
| BRINZOLAMIDE | 23 | 0.6% | 0 | 23 | 0 |
| LEVETIRACETAM | 23 | 0.0% | 17 | 14 | 11 |
| PYRIDOXINE | 23 | 1.0% | 0 | 23 | 0 |
| ZOPICLONE | 23 | 0.2% | 0 | 23 | 0 |
| DICLOFENAC | 22 | 0.0% | 0 | 21 | 0 |