Fracture nonunion: Which Medications Cause It? (702 Reports Across 25 Drugs)
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Fracture nonunion has been reported as an adverse event with 25 different drugs in the FDA's FAERS database, with 702 total reports. 14 of these reports resulted in death.The drugs most commonly associated with Fracture nonunion are ALENDRONATE, FOSAMAX, and ALENDRONATE\CHOLECALCIFEROL.
702
Total Reports
25
Drugs Involved
14
Deaths
535
Hospitalizations
59.1 yrs
Average Patient Age
87.9% / 12.1%
Female / Male
Which Drugs Cause Fracture nonunion Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| ALENDRONATE | 410 | 1.5% | 9 | 378 | 1 |
| FOSAMAX | 92 | 9.6% | 2 | 90 | 1 |
| ALENDRONATE\CHOLECALCIFEROL | 69 | 2.7% | 2 | 68 | 0 |
| IBANDRONATE | 67 | 0.7% | 0 | 64 | 0 |
| RISEDRONATE | 46 | 0.7% | 0 | 31 | 0 |
| ADALIMUMAB | 42 | 0.0% | 0 | 25 | 0 |
| DENOSUMAB | 38 | 0.0% | 0 | 14 | 0 |
| ZOLEDRONIC ACID | 36 | 0.1% | 0 | 19 | 0 |
| FOSAMAX PLUS D | 23 | 16.4% | 1 | 23 | 0 |
| METHOTREXATE | 20 | 0.0% | 0 | 14 | 0 |
| TERIPARATIDE | 15 | 0.0% | 0 | 9 | 0 |
| ACTONEL | 14 | 9.2% | 0 | 13 | 0 |
| ETANERCEPT | 13 | 0.0% | 1 | 4 | 1 |
| ALENDRONIC ACID | 12 | 0.2% | 0 | 6 | 0 |
| IBANDRONIC ACID | 10 | 0.3% | 0 | 0 | 0 |
| ABALOPARATIDE | 9 | 0.0% | 0 | 1 | 0 |
| BONIVA | 9 | 6.9% | 0 | 9 | 0 |
| RALOXIFENE | 8 | 0.2% | 0 | 1 | 0 |
| ETIDRONATE | 7 | 7.4% | 0 | 1 | 0 |
| PREDNISOLONE | 7 | 0.0% | 0 | 2 | 0 |