Gastrointestinal toxicity: Which Medications Cause It? (3,593 Reports Across 270 Drugs)
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Gastrointestinal toxicity has been reported as an adverse event with 270 different drugs in the FDA's FAERS database, with 3,593 total reports. 464 of these reports resulted in death.The drugs most commonly associated with Gastrointestinal toxicity are CAPECITABINE, FLUOROURACIL, and METHOTREXATE.
3,593
Total Reports
270
Drugs Involved
464
Deaths
1,058
Hospitalizations
56.0 yrs
Average Patient Age
60.7% / 39.3%
Female / Male
Which Drugs Cause Gastrointestinal toxicity Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| CAPECITABINE | 368 | 0.6% | 48 | 121 | 13 |
| FLUOROURACIL | 358 | 0.7% | 46 | 122 | 27 |
| METHOTREXATE | 345 | 0.1% | 39 | 160 | 46 |
| OXALIPLATIN | 314 | 0.6% | 53 | 106 | 16 |
| CYCLOPHOSPHAMIDE | 266 | 0.2% | 57 | 33 | 18 |
| RITUXIMAB | 262 | 0.2% | 71 | 116 | 20 |
| CISPLATIN | 251 | 0.5% | 39 | 35 | 15 |
| DOXORUBICIN | 242 | 0.3% | 59 | 37 | 21 |
| IRINOTECAN | 232 | 0.8% | 36 | 109 | 19 |
| CARBOPLATIN | 231 | 0.3% | 41 | 71 | 13 |
| BORTEZOMIB | 208 | 0.4% | 10 | 30 | 4 |
| PACLITAXEL | 206 | 0.3% | 24 | 57 | 8 |
| LEUCOVORIN | 196 | 0.8% | 32 | 64 | 16 |
| BEVACIZUMAB | 181 | 0.2% | 32 | 62 | 14 |
| DEXAMETHASONE | 170 | 0.1% | 29 | 34 | 9 |
| VINCRISTINE | 168 | 0.2% | 46 | 23 | 14 |
| HYDROXYCHLOROQUINE | 166 | 0.3% | 15 | 92 | 14 |
| ADALIMUMAB | 162 | 0.0% | 16 | 111 | 16 |
| ETANERCEPT | 159 | 0.0% | 17 | 96 | 16 |
| SULFASALAZINE | 157 | 0.4% | 15 | 96 | 15 |