Heavy menstrual bleeding: Which Medications Cause It? (6,243 Reports Across 227 Drugs)
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Heavy menstrual bleeding has been reported as an adverse event with 227 different drugs in the FDA's FAERS database, with 6,243 total reports. 23 of these reports resulted in death.The drugs most commonly associated with Heavy menstrual bleeding are ETONOGESTREL, LEVONORGESTREL, and COPPER.
6,243
Total Reports
227
Drugs Involved
23
Deaths
702
Hospitalizations
33.7 yrs
Average Patient Age
99.9% / 0.1%
Female / Male
Which Drugs Cause Heavy menstrual bleeding Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| ETONOGESTREL | 911 | 2.1% | 0 | 35 | 10 |
| LEVONORGESTREL | 863 | 0.8% | 0 | 38 | 11 |
| COPPER | 811 | 2.1% | 1 | 21 | 3 |
| DROSPIRENONE | 436 | 13.3% | 0 | 3 | 2 |
| ESTRADIOL\NORETHINDRONE\RELUGOLIX | 243 | 14.9% | 1 | 8 | 0 |
| RIVAROXABAN | 87 | 0.1% | 0 | 37 | 4 |
| DUPILUMAB | 85 | 0.0% | 0 | 5 | 0 |
| NORGESTREL | 85 | 20.9% | 0 | 0 | 0 |
| ADALIMUMAB | 82 | 0.0% | 3 | 20 | 1 |
| TIRZEPATIDE | 72 | 0.1% | 0 | 1 | 1 |
| ELAGOLIX\ESTRADIOL\NORETHINDRONE | 67 | 10.1% | 0 | 8 | 0 |
| APIXABAN | 66 | 0.0% | 0 | 18 | 5 |
| MEDROXYPROGESTERONE | 65 | 0.8% | 0 | 10 | 5 |
| METHOTREXATE | 65 | 0.0% | 3 | 20 | 2 |
| SERTRALINE | 60 | 0.1% | 0 | 7 | 5 |
| ETHINYL ESTRADIOL\LEVONORGESTREL | 58 | 1.3% | 0 | 11 | 1 |
| OCRELIZUMAB | 55 | 0.1% | 0 | 15 | 0 |
| SEMAGLUTIDE | 54 | 0.1% | 0 | 1 | 2 |
| TREPROSTINIL | 54 | 0.1% | 3 | 24 | 0 |
| ELAGOLIX | 52 | 1.5% | 0 | 5 | 1 |