Hepatic enzyme increased: Which Medications Cause It? (49,294 Reports Across 1,349 Drugs)
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Hepatic enzyme increased has been reported as an adverse event with 1,349 different drugs in the FDA's FAERS database, with 49,294 total reports. 4,066 of these reports resulted in death.The drugs most commonly associated with Hepatic enzyme increased are METHOTREXATE, ADALIMUMAB, and TOCILIZUMAB.
49,294
Total Reports
1,349
Drugs Involved
4,066
Deaths
14,600
Hospitalizations
52.2 yrs
Average Patient Age
68.7% / 31.3%
Female / Male
Which Drugs Cause Hepatic enzyme increased Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| METHOTREXATE | 9,857 | 3.9% | 1,881 | 3,220 | 2,130 |
| ADALIMUMAB | 8,693 | 1.7% | 1,935 | 3,052 | 2,089 |
| TOCILIZUMAB | 7,691 | 7.8% | 2,026 | 2,765 | 2,037 |
| ETANERCEPT | 7,481 | 2.1% | 1,528 | 2,302 | 1,694 |
| ABATACEPT | 7,397 | 6.4% | 1,747 | 2,707 | 2,099 |
| RITUXIMAB | 7,247 | 4.1% | 1,980 | 2,925 | 2,104 |
| LEFLUNOMIDE | 7,173 | 12.7% | 1,826 | 2,823 | 2,202 |
| INFLIXIMAB | 6,778 | 4.8% | 1,883 | 2,546 | 2,037 |
| HYDROXYCHLOROQUINE | 6,555 | 9.8% | 1,708 | 2,532 | 1,965 |
| TOFACITINIB | 6,269 | 4.0% | 1,602 | 2,323 | 1,848 |
| PREDNISONE | 5,897 | 3.7% | 1,779 | 2,568 | 2,074 |
| SULFASALAZINE | 5,784 | 14.4% | 1,647 | 2,375 | 1,939 |
| CERTOLIZUMAB PEGOL | 5,428 | 5.5% | 1,740 | 2,319 | 1,979 |
| CETIRIZINE | 5,385 | 11.3% | 1,916 | 2,233 | 2,044 |
| ACETAMINOPHEN | 5,341 | 3.9% | 1,750 | 2,570 | 1,941 |
| DICLOFENAC | 5,156 | 5.9% | 1,959 | 2,271 | 2,042 |
| GOLIMUMAB | 5,115 | 7.4% | 1,678 | 2,248 | 1,929 |
| FOLIC ACID | 5,016 | 21.9% | 1,744 | 2,225 | 1,973 |
| ALENDRONATE | 4,927 | 17.7% | 1,800 | 2,381 | 2,066 |
| DESOXIMETASONE | 4,861 | 41.8% | 1,736 | 2,148 | 1,993 |