Hepatic function abnormal: Which Medications Cause It? (25,210 Reports Across 956 Drugs)
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Hepatic function abnormal has been reported as an adverse event with 956 different drugs in the FDA's FAERS database, with 25,210 total reports. 3,249 of these reports resulted in death.The drugs most commonly associated with Hepatic function abnormal are NIVOLUMAB, PEMBROLIZUMAB, and METHOTREXATE.
25,210
Total Reports
956
Drugs Involved
3,249
Deaths
11,444
Hospitalizations
56.4 yrs
Average Patient Age
47.2% / 52.8%
Female / Male
Which Drugs Cause Hepatic function abnormal Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| NIVOLUMAB | 1,131 | 1.3% | 283 | 636 | 115 |
| PEMBROLIZUMAB | 1,079 | 1.3% | 180 | 673 | 100 |
| METHOTREXATE | 1,054 | 0.4% | 88 | 311 | 59 |
| CABOZANTINIB S-MALATE | 912 | 2.3% | 43 | 124 | 13 |
| CYCLOPHOSPHAMIDE | 824 | 0.6% | 82 | 340 | 45 |
| BEVACIZUMAB | 769 | 1.0% | 137 | 268 | 26 |
| PACLITAXEL | 603 | 0.8% | 73 | 300 | 33 |
| LENVATINIB | 528 | 1.6% | 66 | 345 | 21 |
| ATORVASTATIN | 520 | 0.7% | 17 | 270 | 36 |
| CYCLOSPORINE | 508 | 0.7% | 67 | 130 | 20 |
| CARBOPLATIN | 498 | 0.6% | 68 | 244 | 52 |
| IPILIMUMAB | 492 | 1.4% | 108 | 334 | 60 |
| ATEZOLIZUMAB | 490 | 1.5% | 96 | 235 | 16 |
| PREDNISOLONE | 486 | 0.6% | 138 | 293 | 74 |
| TRASTUZUMAB | 480 | 1.0% | 20 | 201 | 14 |
| CAPECITABINE | 476 | 0.8% | 39 | 134 | 19 |
| ADALIMUMAB | 468 | 0.1% | 15 | 98 | 12 |
| TOCILIZUMAB | 460 | 0.5% | 23 | 76 | 14 |
| EPIRUBICIN | 448 | 2.8% | 13 | 160 | 8 |
| ACETAMINOPHEN | 437 | 0.3% | 55 | 286 | 91 |