Hyperleukocytosis: Which Medications Cause It? (821 Reports Across 165 Drugs)
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Hyperleukocytosis has been reported as an adverse event with 165 different drugs in the FDA's FAERS database, with 821 total reports. 166 of these reports resulted in death.The drugs most commonly associated with Hyperleukocytosis are CYCLOPHOSPHAMIDE, PREDNISONE, and TRETINOIN.
821
Total Reports
165
Drugs Involved
166
Deaths
466
Hospitalizations
51.6 yrs
Average Patient Age
34.0% / 66.0%
Female / Male
Which Drugs Cause Hyperleukocytosis Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| CYCLOPHOSPHAMIDE | 55 | 0.0% | 17 | 10 | 0 |
| PREDNISONE | 54 | 0.0% | 3 | 44 | 3 |
| TRETINOIN | 52 | 1.3% | 1 | 26 | 3 |
| ARSENIC TRIOXIDE | 49 | 4.2% | 1 | 26 | 2 |
| RITUXIMAB | 49 | 0.0% | 22 | 14 | 3 |
| ACETAMINOPHEN | 44 | 0.0% | 10 | 42 | 2 |
| VINCRISTINE | 44 | 0.1% | 20 | 14 | 2 |
| DEXAMETHASONE | 42 | 0.0% | 20 | 22 | 7 |
| PANTOPRAZOLE | 38 | 0.1% | 0 | 38 | 2 |
| AMOXICILLIN | 36 | 0.1% | 19 | 19 | 0 |
| DOXORUBICIN | 36 | 0.0% | 16 | 6 | 0 |
| ALPRAZOLAM | 33 | 0.1% | 12 | 27 | 3 |
| SULFAMETHOXAZOLE\TRIMETHOPRIM | 33 | 0.1% | 0 | 33 | 4 |
| LOXAPINE | 28 | 0.7% | 9 | 17 | 1 |
| AMLODIPINE | 27 | 0.0% | 0 | 23 | 1 |
| CYTARABINE | 27 | 0.1% | 12 | 5 | 1 |
| IMATINIB | 26 | 0.1% | 8 | 5 | 0 |
| CARBOPLATIN | 25 | 0.0% | 3 | 15 | 0 |
| INFLIXIMAB | 25 | 0.0% | 0 | 15 | 0 |
| VALACYCLOVIR | 25 | 0.2% | 0 | 25 | 0 |