Hypothalamic pituitary adrenal axis suppression: Which Medications Cause It? (310 Reports Across 35 Drugs)
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Hypothalamic pituitary adrenal axis suppression has been reported as an adverse event with 35 different drugs in the FDA's FAERS database, with 310 total reports. 8 of these reports resulted in death.The drugs most commonly associated with Hypothalamic pituitary adrenal axis suppression are TRIAMCINOLONE ACETONIDE, CLOBETASOL, and DEXAMETHASONE.
310
Total Reports
35
Drugs Involved
8
Deaths
139
Hospitalizations
43.1 yrs
Average Patient Age
47.1% / 52.9%
Female / Male
Which Drugs Cause Hypothalamic pituitary adrenal axis suppression Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| TRIAMCINOLONE ACETONIDE | 42 | 0.3% | 0 | 20 | 0 |
| CLOBETASOL | 35 | 0.5% | 1 | 18 | 2 |
| DEXAMETHASONE | 35 | 0.0% | 2 | 17 | 9 |
| HYDROCORTISONE | 29 | 0.1% | 0 | 11 | 0 |
| OXYCODONE | 21 | 0.0% | 0 | 12 | 3 |
| TRIAMCINOLONE | 21 | 0.3% | 0 | 8 | 0 |
| FLUTICASONE | 17 | 0.1% | 0 | 6 | 1 |
| BUDESONIDE | 16 | 0.1% | 0 | 3 | 1 |
| PREDNISONE | 16 | 0.0% | 2 | 11 | 4 |
| BETAMETHASONE | 15 | 0.2% | 0 | 5 | 0 |
| PREDNISOLONE | 13 | 0.0% | 0 | 5 | 2 |
| TESTOSTERONE | 12 | 0.0% | 3 | 8 | 6 |
| METHYLPREDNISOLONE | 10 | 0.0% | 0 | 5 | 2 |
| ANASTROZOLE | 8 | 0.1% | 0 | 8 | 7 |
| CLOMIPHENE | 8 | 1.2% | 0 | 8 | 7 |
| FUROSEMIDE | 8 | 0.0% | 0 | 8 | 0 |
| LIOTHYRONINE | 8 | 0.3% | 0 | 8 | 7 |
| METFORMIN | 8 | 0.0% | 0 | 8 | 0 |
| POTASSIUM | 8 | 0.1% | 0 | 8 | 0 |
| VENLAFAXINE | 8 | 0.0% | 0 | 8 | 0 |