Immune reconstitution inflammatory syndrome: Which Medications Cause It? (4,446 Reports Across 211 Drugs)
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Immune reconstitution inflammatory syndrome has been reported as an adverse event with 211 different drugs in the FDA's FAERS database, with 4,446 total reports. 587 of these reports resulted in death.The drugs most commonly associated with Immune reconstitution inflammatory syndrome are NATALIZUMAB, LAMIVUDINE, and DOLUTEGRAVIR.
4,446
Total Reports
211
Drugs Involved
587
Deaths
2,571
Hospitalizations
44.0 yrs
Average Patient Age
44.9% / 55.1%
Female / Male
Which Drugs Cause Immune reconstitution inflammatory syndrome Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| NATALIZUMAB | 1,042 | 1.6% | 127 | 843 | 92 |
| LAMIVUDINE | 625 | 3.8% | 88 | 279 | 31 |
| DOLUTEGRAVIR | 403 | 3.7% | 58 | 208 | 28 |
| TENOFOVIR DISOPROXIL | 401 | 1.5% | 50 | 185 | 12 |
| EFAVIRENZ | 301 | 3.8% | 47 | 148 | 15 |
| TACROLIMUS | 269 | 0.3% | 82 | 175 | 63 |
| EMTRICITABINE | 262 | 7.1% | 49 | 140 | 11 |
| EMTRICITABINE\TENOFOVIR DISOPROXIL | 228 | 0.6% | 23 | 125 | 9 |
| ETHAMBUTOL | 202 | 2.7% | 19 | 100 | 7 |
| ABACAVIR | 200 | 4.7% | 42 | 116 | 18 |
| PREDNISONE | 192 | 0.1% | 32 | 128 | 27 |
| RITONAVIR | 189 | 1.6% | 29 | 112 | 12 |
| ZIDOVUDINE | 182 | 2.7% | 31 | 67 | 3 |
| METHOTREXATE | 181 | 0.1% | 8 | 89 | 8 |
| RIFAMPIN | 180 | 1.4% | 18 | 91 | 7 |
| TENOFOVIR | 177 | 4.4% | 33 | 75 | 7 |
| MYCOPHENOLATE MOFETIL | 176 | 0.2% | 44 | 99 | 32 |
| RALTEGRAVIR | 174 | 2.0% | 19 | 86 | 6 |
| PREDNISOLONE | 163 | 0.2% | 35 | 98 | 22 |
| FINGOLIMOD | 160 | 0.2% | 6 | 102 | 15 |