International normalised ratio fluctuation: Which Medications Cause It? (1,235 Reports Across 73 Drugs)
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International normalised ratio fluctuation has been reported as an adverse event with 73 different drugs in the FDA's FAERS database, with 1,235 total reports. 30 of these reports resulted in death.The drugs most commonly associated with International normalised ratio fluctuation are WARFARIN, ADALIMUMAB, and METHOTREXATE.
1,235
Total Reports
73
Drugs Involved
30
Deaths
309
Hospitalizations
67.2 yrs
Average Patient Age
59.3% / 40.7%
Female / Male
Which Drugs Cause International normalised ratio fluctuation Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| WARFARIN | 738 | 1.8% | 17 | 130 | 20 |
| ADALIMUMAB | 167 | 0.0% | 0 | 44 | 6 |
| METHOTREXATE | 159 | 0.1% | 0 | 42 | 4 |
| BISOPROLOL | 155 | 0.6% | 1 | 47 | 5 |
| LEFLUNOMIDE | 150 | 0.3% | 0 | 43 | 4 |
| CELECOXIB | 149 | 0.5% | 0 | 41 | 4 |
| LEVOFLOXACIN | 149 | 0.4% | 1 | 43 | 4 |
| NORFLOXACIN | 149 | 18.7% | 0 | 42 | 4 |
| PREDNISONE | 149 | 0.1% | 0 | 44 | 6 |
| CEFACLOR | 148 | 14.1% | 0 | 41 | 4 |
| MEPERIDINE | 148 | 2.3% | 0 | 41 | 4 |
| SULFASALAZINE | 147 | 0.4% | 0 | 42 | 4 |
| DICLOFENAC\MISOPROSTOL | 144 | 9.2% | 0 | 41 | 4 |
| PREGABALIN | 144 | 0.1% | 0 | 42 | 4 |
| ERYTHROMYCIN | 142 | 1.9% | 0 | 42 | 4 |
| HYDROXYCHLOROQUINE | 142 | 0.2% | 0 | 42 | 4 |
| METRONIDAZOLE | 137 | 0.6% | 0 | 40 | 4 |
| ERYTHROMYCIN ESTOLATE | 68 | 69.4% | 0 | 33 | 3 |
| MISOPROSTOL | 64 | 1.8% | 0 | 40 | 4 |
| METRONIDAZOLE\METRONIDAZOLE | 51 | 1.2% | 0 | 35 | 4 |