Irritability: Which Medications Cause It? (40,220 Reports Across 962 Drugs)
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Irritability has been reported as an adverse event with 962 different drugs in the FDA's FAERS database, with 40,220 total reports. 622 of these reports resulted in death.The drugs most commonly associated with Irritability are DULOXETINE, LEVOTHYROXINE, and LEVETIRACETAM.
40,220
Total Reports
962
Drugs Involved
622
Deaths
6,017
Hospitalizations
43.6 yrs
Average Patient Age
59.8% / 40.2%
Female / Male
Which Drugs Cause Irritability Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| DULOXETINE | 3,554 | 6.8% | 25 | 304 | 44 |
| LEVOTHYROXINE | 1,692 | 2.7% | 1 | 120 | 12 |
| LEVETIRACETAM | 1,067 | 1.7% | 10 | 246 | 21 |
| ARIPIPRAZOLE | 851 | 1.3% | 1 | 297 | 24 |
| LEVONORGESTREL | 796 | 0.7% | 2 | 47 | 18 |
| RIBAVIRIN | 775 | 1.8% | 12 | 51 | 6 |
| AMPHETAMINE ASPARTATE\AMPHETAMINE\DEXTROAMPHETAMINE SACCHARATE\DEXTROAMPHETAMINE | 745 | 4.7% | 1 | 32 | 11 |
| PREGABALIN | 736 | 0.7% | 5 | 150 | 19 |
| METHYLPHENIDATE | 735 | 2.4% | 1 | 91 | 12 |
| QUETIAPINE | 638 | 0.9% | 25 | 279 | 35 |
| PEGINTERFERON ALFA-2A | 612 | 2.5% | 6 | 25 | 7 |
| MONTELUKAST | 572 | 2.1% | 4 | 54 | 56 |
| SERTRALINE | 567 | 1.0% | 6 | 162 | 40 |
| BUPROPION | 554 | 1.6% | 10 | 72 | 14 |
| RISPERIDONE | 513 | 0.7% | 20 | 261 | 21 |
| VENLAFAXINE | 511 | 1.1% | 4 | 113 | 20 |
| OLANZAPINE | 509 | 1.0% | 7 | 286 | 32 |
| ADALIMUMAB | 507 | 0.1% | 15 | 88 | 7 |
| OXYCODONE | 500 | 0.3% | 42 | 131 | 16 |
| GABAPENTIN | 484 | 0.7% | 12 | 146 | 18 |