Major depression: Which Medications Cause It? (4,941 Reports Across 334 Drugs)
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Major depression has been reported as an adverse event with 334 different drugs in the FDA's FAERS database, with 4,941 total reports. 191 of these reports resulted in death.The drugs most commonly associated with Major depression are VENLAFAXINE, OXYCODONE, and TRAMADOL.
4,941
Total Reports
334
Drugs Involved
191
Deaths
1,660
Hospitalizations
47.0 yrs
Average Patient Age
61.6% / 38.4%
Female / Male
Which Drugs Cause Major depression Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| VENLAFAXINE | 356 | 0.7% | 1 | 100 | 50 |
| OXYCODONE | 327 | 0.2% | 44 | 108 | 10 |
| TRAMADOL | 324 | 0.4% | 20 | 52 | 33 |
| ESCITALOPRAM OXALATE | 272 | 0.9% | 2 | 42 | 40 |
| FLUOXETINE | 249 | 0.8% | 0 | 35 | 37 |
| ACETAMINOPHEN | 234 | 0.2% | 3 | 38 | 48 |
| ACETAMINOPHEN\HYDROCODONE | 208 | 0.2% | 29 | 67 | 7 |
| ESOMEPRAZOLE | 203 | 0.3% | 2 | 16 | 36 |
| ACETAMINOPHEN\OXYCODONE | 195 | 0.2% | 33 | 65 | 2 |
| SODIUM OXYBATE | 189 | 0.3% | 0 | 26 | 0 |
| TOFACITINIB | 187 | 0.1% | 0 | 10 | 37 |
| AMLODIPINE | 178 | 0.3% | 1 | 3 | 31 |
| MOCLOBEMIDE | 176 | 38.2% | 0 | 8 | 33 |
| MONTELUKAST | 170 | 0.6% | 1 | 64 | 14 |
| VALSARTAN | 166 | 0.8% | 0 | 2 | 29 |
| QUETIAPINE | 158 | 0.2% | 6 | 103 | 28 |
| MORPHINE | 149 | 0.1% | 17 | 49 | 4 |
| HYDROMORPHONE | 148 | 0.2% | 20 | 52 | 5 |
| ARIPIPRAZOLE | 142 | 0.2% | 3 | 56 | 9 |
| DULOXETINE | 128 | 0.3% | 1 | 41 | 11 |