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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Medication overuse headache: Which Medications Cause It? (770 Reports Across 64 Drugs)

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Medication overuse headache has been reported as an adverse event with 64 different drugs in the FDA's FAERS database, with 770 total reports. The drugs most commonly associated with Medication overuse headache are ACETAMINOPHEN\ASPIRIN\CAFFEINE, SUMATRIPTAN, and IBUPROFEN.

770
Total Reports
64
Drugs Involved
0
Deaths
178
Hospitalizations
46.9 yrs
Average Patient Age
81.8% / 18.2%
Female / Male

Which Drugs Cause Medication overuse headache Most Often?

Drug Reports % of Drug Reports Deaths Hosp. Life-Threat.
ACETAMINOPHEN\ASPIRIN\CAFFEINE 192 1.6% 0 4 0
SUMATRIPTAN 131 0.8% 0 46 1
IBUPROFEN 95 0.1% 0 42 1
TOPIRAMATE 91 0.3% 0 31 1
ACETAMINOPHEN 89 0.1% 0 41 0
ELETRIPTAN HYDROBROMIDE 46 2.1% 0 10 0
ERENUMAB-AOOE 46 0.1% 0 0 0
ZOLMITRIPTAN 38 2.3% 0 26 0
NAPROXEN 34 0.1% 0 23 0
AMITRIPTYLINE 32 0.2% 0 17 1
RIMEGEPANT 31 0.3% 0 2 0
VALPROIC ACID 31 0.2% 0 13 0
PROPRANOLOL 28 0.1% 0 2 1
VENLAFAXINE 28 0.1% 0 6 1
METOPROLOL 26 0.1% 0 0 0
OXYCODONE 25 0.0% 0 20 0
HYDROMORPHONE 23 0.0% 0 1 0
ACETAMINOPHEN\OXYCODONE 21 0.0% 0 0 0
RIZATRIPTAN 20 0.7% 0 11 0
VERAPAMIL 20 0.2% 0 0 0

View all 64 drugs →

Top 3 Drugs Associated With Medication overuse headache

131 reports
95 reports

Related Side Effects

Drug ineffective (1,049,718) Off label use (762,782) Death (660,423) Fatigue (599,248) Nausea (562,301) Diarrhoea (491,550) Pain (471,975) Headache (460,069) Dyspnoea (409,496) Dizziness (352,922)