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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Migraine: Which Medications Cause It? (71,765 Reports Across 1,294 Drugs)

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Migraine has been reported as an adverse event with 1,294 different drugs in the FDA's FAERS database, with 71,765 total reports. 1,564 of these reports resulted in death.The drugs most commonly associated with Migraine are ERENUMAB-AOOE, ADALIMUMAB, and GALCANEZUMAB-GNLM.

71,765
Total Reports
1,294
Drugs Involved
1,564
Deaths
12,677
Hospitalizations
46.9 yrs
Average Patient Age
84.8% / 15.2%
Female / Male

Which Drugs Cause Migraine Most Often?

Drug Reports % of Drug Reports Deaths Hosp. Life-Threat.
ERENUMAB-AOOE 4,290 8.6% 468 736 480
ADALIMUMAB 4,238 0.9% 869 1,615 1,079
GALCANEZUMAB-GNLM 2,612 9.8% 0 94 3
METHOTREXATE 2,532 1.0% 900 1,216 1,145
ETANERCEPT 2,320 0.7% 679 882 826
PREDNISONE 2,203 1.4% 847 1,134 1,040
APREMILAST 2,154 1.6% 705 808 793
INFLIXIMAB 2,137 1.5% 775 1,079 974
RITUXIMAB 1,894 1.1% 994 1,206 1,118
TOFACITINIB 1,878 1.2% 688 869 870
SECUKINUMAB 1,875 1.2% 901 1,066 1,120
NAPROXEN 1,822 3.5% 720 900 977
TOPIRAMATE 1,796 6.3% 371 558 393
CETIRIZINE 1,726 3.6% 793 999 1,105
DICLOFENAC 1,712 2.0% 929 1,087 1,146
TOCILIZUMAB 1,656 1.7% 855 1,066 1,013
ABATACEPT 1,623 1.4% 780 1,003 1,086
ACETAMINOPHEN 1,599 1.2% 713 847 858
CERTOLIZUMAB PEGOL 1,594 1.6% 751 883 958
LEFLUNOMIDE 1,584 2.8% 854 993 1,076

View all 1,294 drugs →

Top 3 Drugs Associated With Migraine

4,290 reports
4,238 reports
2,612 reports

Related Side Effects

Drug ineffective (1,049,718) Off label use (762,782) Death (660,423) Fatigue (599,248) Nausea (562,301) Diarrhoea (491,550) Pain (471,975) Headache (460,069) Dyspnoea (409,496) Dizziness (352,922)