Neuroleptic malignant syndrome: Which Medications Cause It? (7,446 Reports Across 302 Drugs)
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Neuroleptic malignant syndrome has been reported as an adverse event with 302 different drugs in the FDA's FAERS database, with 7,446 total reports. 863 of these reports resulted in death.The drugs most commonly associated with Neuroleptic malignant syndrome are QUETIAPINE, OLANZAPINE, and RISPERIDONE.
7,446
Total Reports
302
Drugs Involved
863
Deaths
5,150
Hospitalizations
47.1 yrs
Average Patient Age
38.4% / 61.6%
Female / Male
Which Drugs Cause Neuroleptic malignant syndrome Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| QUETIAPINE | 1,756 | 2.4% | 204 | 1,289 | 621 |
| OLANZAPINE | 1,748 | 3.4% | 171 | 1,232 | 597 |
| RISPERIDONE | 1,258 | 1.6% | 151 | 947 | 363 |
| HALOPERIDOL | 1,244 | 7.8% | 118 | 898 | 464 |
| ARIPIPRAZOLE | 1,138 | 1.7% | 134 | 807 | 354 |
| CLOZAPINE | 899 | 0.9% | 79 | 634 | 189 |
| LITHIUM | 506 | 3.4% | 46 | 379 | 158 |
| LORAZEPAM | 437 | 1.3% | 42 | 363 | 160 |
| PALIPERIDONE | 355 | 0.9% | 43 | 258 | 69 |
| VALPROIC ACID | 352 | 1.8% | 29 | 261 | 103 |
| SERTRALINE | 309 | 0.5% | 32 | 256 | 105 |
| MIRTAZAPINE | 269 | 0.9% | 38 | 193 | 84 |
| CLONAZEPAM | 263 | 0.7% | 31 | 221 | 89 |
| DIAZEPAM | 248 | 0.7% | 37 | 197 | 124 |
| VENLAFAXINE | 194 | 0.4% | 25 | 118 | 61 |
| CHLORPROMAZINE | 186 | 4.7% | 10 | 157 | 71 |
| PAROXETINE | 175 | 0.8% | 28 | 142 | 83 |
| ESCITALOPRAM OXALATE | 170 | 0.6% | 31 | 102 | 39 |
| ZIPRASIDONE | 166 | 4.7% | 22 | 140 | 79 |
| LAMOTRIGINE | 159 | 0.3% | 13 | 124 | 38 |