Osteonecrosis of jaw: Which Medications Cause It? (17,864 Reports Across 256 Drugs)
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Osteonecrosis of jaw has been reported as an adverse event with 256 different drugs in the FDA's FAERS database, with 17,864 total reports. 755 of these reports resulted in death.The drugs most commonly associated with Osteonecrosis of jaw are DENOSUMAB, ZOLEDRONIC ACID, and ALENDRONATE.
17,864
Total Reports
256
Drugs Involved
755
Deaths
3,785
Hospitalizations
68.4 yrs
Average Patient Age
66.6% / 33.4%
Female / Male
Which Drugs Cause Osteonecrosis of jaw Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| DENOSUMAB | 8,438 | 5.7% | 303 | 1,486 | 58 |
| ZOLEDRONIC ACID | 5,500 | 16.4% | 216 | 1,278 | 51 |
| ALENDRONATE | 1,017 | 3.7% | 48 | 354 | 17 |
| LENALIDOMIDE | 461 | 0.1% | 11 | 135 | 6 |
| ALENDRONIC ACID | 434 | 5.4% | 6 | 90 | 6 |
| IBANDRONATE | 422 | 4.2% | 11 | 104 | 10 |
| PALBOCICLIB | 388 | 0.4% | 5 | 113 | 2 |
| ZOMETA | 386 | 44.4% | 78 | 177 | 4 |
| LETROZOLE | 339 | 1.1% | 18 | 142 | 0 |
| DEXAMETHASONE | 321 | 0.3% | 20 | 152 | 14 |
| PAMIDRONATE | 313 | 19.1% | 39 | 71 | 8 |
| RISEDRONATE | 307 | 4.5% | 7 | 107 | 9 |
| PREDNISOLONE | 294 | 0.4% | 15 | 95 | 5 |
| METHOTREXATE | 280 | 0.1% | 4 | 98 | 10 |
| BEVACIZUMAB | 272 | 0.4% | 41 | 56 | 8 |
| EVEROLIMUS | 244 | 0.6% | 13 | 62 | 1 |
| IBANDRONIC ACID | 242 | 8.2% | 3 | 79 | 5 |
| RIBOCICLIB | 240 | 0.9% | 12 | 96 | 2 |
| FULVESTRANT | 231 | 1.3% | 3 | 77 | 0 |
| DOCETAXEL | 214 | 0.3% | 17 | 98 | 10 |