Personality change: Which Medications Cause It? (5,703 Reports Across 329 Drugs)
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Personality change has been reported as an adverse event with 329 different drugs in the FDA's FAERS database, with 5,703 total reports. 426 of these reports resulted in death.The drugs most commonly associated with Personality change are OLANZAPINE, ARIPIPRAZOLE, and QUETIAPINE.
5,703
Total Reports
329
Drugs Involved
426
Deaths
1,372
Hospitalizations
44.2 yrs
Average Patient Age
51.3% / 48.7%
Female / Male
Which Drugs Cause Personality change Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| OLANZAPINE | 471 | 0.9% | 42 | 49 | 14 |
| ARIPIPRAZOLE | 468 | 0.7% | 41 | 46 | 16 |
| QUETIAPINE | 467 | 0.6% | 46 | 39 | 20 |
| RISPERIDONE | 435 | 0.6% | 40 | 41 | 22 |
| CLOZAPINE | 423 | 0.4% | 41 | 32 | 1 |
| PALIPERIDONE | 414 | 1.0% | 41 | 18 | 11 |
| LURASIDONE | 408 | 2.4% | 43 | 4 | 2 |
| OXYCODONE | 386 | 0.2% | 110 | 66 | 5 |
| ASENAPINE | 384 | 13.4% | 41 | 2 | 0 |
| ZIPRASIDONE | 379 | 10.7% | 41 | 2 | 0 |
| ZUCLOPENTHIXOL | 340 | 14.1% | 41 | 3 | 0 |
| FLUPENTIXOL | 330 | 28.9% | 34 | 2 | 0 |
| ZUCLOPENTHIXOL DECANOATE | 225 | 37.0% | 39 | 1 | 0 |
| ACETAMINOPHEN\HYDROCODONE | 180 | 0.2% | 42 | 35 | 3 |
| ACETAMINOPHEN\OXYCODONE | 180 | 0.2% | 42 | 30 | 3 |
| LEVETIRACETAM | 176 | 0.3% | 2 | 74 | 6 |
| FLUPENTIXOL DECANOATE | 173 | 44.5% | 35 | 2 | 0 |
| MONTELUKAST | 172 | 0.6% | 0 | 6 | 6 |
| MORPHINE | 159 | 0.1% | 56 | 31 | 4 |
| TRAMADOL | 127 | 0.2% | 27 | 35 | 15 |