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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Polysubstance dependence: Which Medications Cause It? (50 Reports Across 13 Drugs)

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Polysubstance dependence has been reported as an adverse event with 13 different drugs in the FDA's FAERS database, with 50 total reports. 3 of these reports resulted in death.The drugs most commonly associated with Polysubstance dependence are OXYCODONE, COCAINE, and HYDROMORPHONE.

50
Total Reports
13
Drugs Involved
3
Deaths
6
Hospitalizations
30.2 yrs
Average Patient Age
31.4% / 68.6%
Female / Male

Which Drugs Cause Polysubstance dependence Most Often?

Drug Reports % of Drug Reports Deaths Hosp. Life-Threat.
OXYCODONE 18 0.0% 2 3 0
COCAINE 17 0.1% 0 0 0
HYDROMORPHONE 12 0.0% 0 0 0
MORPHINE 12 0.0% 0 0 0
ALCOHOL 11 0.1% 1 1 0
CANNABIS SATIVA SUBSP. INDICA TOP 10 0.1% 0 1 0
OXYCONTIN 10 1.2% 1 1 1
HEROIN 6 0.7% 1 0 0
METHAMPHETAMINE 6 0.1% 0 1 1
DIACETYLMORPHINE 5 0.2% 0 1 0
METHYLENEDIOXYMETHAMPHETAMINE 5 6.0% 0 1 0
NICOTINE 5 0.0% 1 1 0
UNSPECIFIED INGREDIENT 5 0.0% 1 1 0

View all 13 drugs →

Top 3 Drugs Associated With Polysubstance dependence

18 reports
17 reports
12 reports

Related Side Effects

Drug ineffective (1,049,718) Off label use (762,782) Death (660,423) Fatigue (599,248) Nausea (562,301) Diarrhoea (491,550) Pain (471,975) Headache (460,069) Dyspnoea (409,496) Dizziness (352,922)