Product substitution issue: Which Medications Cause It? (44,132 Reports Across 625 Drugs)
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Product substitution issue has been reported as an adverse event with 625 different drugs in the FDA's FAERS database, with 44,132 total reports. 156 of these reports resulted in death.The drugs most commonly associated with Product substitution issue are AMPHETAMINE ASPARTATE\AMPHETAMINE\DEXTROAMPHETAMINE SACCHARATE\DEXTROAMPHETAMINE, BUPROPION, and METHYLPHENIDATE.
44,132
Total Reports
625
Drugs Involved
156
Deaths
2,278
Hospitalizations
50.6 yrs
Average Patient Age
65.3% / 34.7%
Female / Male
Which Drugs Cause Product substitution issue Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| AMPHETAMINE ASPARTATE\AMPHETAMINE\DEXTROAMPHETAMINE SACCHARATE\DEXTROAMPHETAMINE | 2,832 | 17.7% | 1 | 30 | 46 |
| BUPROPION | 1,578 | 4.4% | 0 | 25 | 51 |
| METHYLPHENIDATE | 1,408 | 4.5% | 3 | 29 | 22 |
| CLONAZEPAM | 1,288 | 3.3% | 1 | 36 | 15 |
| LAMOTRIGINE | 979 | 2.0% | 15 | 88 | 37 |
| ALBUTEROL | 864 | 0.9% | 2 | 38 | 20 |
| LEVOTHYROXINE | 803 | 1.3% | 4 | 38 | 25 |
| DULOXETINE | 766 | 1.5% | 1 | 41 | 42 |
| ESTRADIOL | 692 | 2.2% | 0 | 5 | 10 |
| SERTRALINE | 636 | 1.1% | 3 | 23 | 12 |
| LEVETIRACETAM | 572 | 0.9% | 21 | 80 | 71 |
| METOPROLOL | 570 | 1.4% | 2 | 67 | 13 |
| VENLAFAXINE | 563 | 1.2% | 0 | 36 | 21 |
| LOSARTAN | 484 | 2.2% | 0 | 35 | 26 |
| ESCITALOPRAM OXALATE | 483 | 1.6% | 1 | 17 | 16 |
| BUPRENORPHINE\NALOXONE | 461 | 2.1% | 3 | 9 | 21 |
| ADALIMUMAB | 460 | 0.1% | 3 | 81 | 11 |
| METFORMIN | 434 | 0.5% | 3 | 44 | 5 |
| GLATIRAMER | 432 | 0.9% | 0 | 25 | 5 |
| ACETAMINOPHEN\HYDROCODONE | 428 | 0.4% | 0 | 11 | 4 |
Top 3 Drugs Associated With Product substitution issue
1,578 reports
1,408 reports