Prothrombin time prolonged: Which Medications Cause It? (2,452 Reports Across 235 Drugs)
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Prothrombin time prolonged has been reported as an adverse event with 235 different drugs in the FDA's FAERS database, with 2,452 total reports. 298 of these reports resulted in death.The drugs most commonly associated with Prothrombin time prolonged are WARFARIN, RIVAROXABAN, and ACETAMINOPHEN.
2,452
Total Reports
235
Drugs Involved
298
Deaths
1,496
Hospitalizations
57.6 yrs
Average Patient Age
52.1% / 47.9%
Female / Male
Which Drugs Cause Prothrombin time prolonged Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| WARFARIN | 257 | 0.6% | 14 | 151 | 18 |
| RIVAROXABAN | 253 | 0.2% | 12 | 115 | 28 |
| ACETAMINOPHEN | 201 | 0.2% | 12 | 175 | 31 |
| ASPIRIN | 102 | 0.1% | 10 | 67 | 10 |
| DABIGATRAN ETEXILATE | 84 | 0.2% | 15 | 68 | 9 |
| APIXABAN | 82 | 0.1% | 2 | 47 | 10 |
| ENOXAPARIN | 52 | 0.2% | 7 | 36 | 8 |
| IBUPROFEN | 49 | 0.1% | 1 | 47 | 11 |
| METHOTREXATE | 49 | 0.0% | 4 | 41 | 3 |
| AMIODARONE | 44 | 0.2% | 3 | 33 | 5 |
| CLOPIDOGREL BISULFATE | 40 | 0.1% | 10 | 27 | 3 |
| CYTARABINE | 39 | 0.1% | 3 | 23 | 1 |
| DEXAMETHASONE | 38 | 0.0% | 4 | 30 | 0 |
| PHENPROCOUMON | 37 | 2.7% | 7 | 31 | 5 |
| METHYLPREDNISOLONE | 35 | 0.1% | 7 | 13 | 10 |
| FUROSEMIDE | 34 | 0.1% | 3 | 27 | 1 |
| PREDNISOLONE | 33 | 0.0% | 10 | 16 | 2 |
| TIGECYCLINE | 32 | 1.0% | 1 | 8 | 6 |
| ATORVASTATIN | 30 | 0.0% | 0 | 17 | 1 |
| BISOPROLOL | 30 | 0.1% | 0 | 22 | 0 |