Restless legs syndrome: Which Medications Cause It? (12,649 Reports Across 547 Drugs)
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Restless legs syndrome has been reported as an adverse event with 547 different drugs in the FDA's FAERS database, with 12,649 total reports. 179 of these reports resulted in death.The drugs most commonly associated with Restless legs syndrome are SODIUM OXYBATE, QUETIAPINE, and MIRTAZAPINE.
12,649
Total Reports
547
Drugs Involved
179
Deaths
2,317
Hospitalizations
54.7 yrs
Average Patient Age
68.6% / 31.4%
Female / Male
Which Drugs Cause Restless legs syndrome Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| SODIUM OXYBATE | 575 | 0.9% | 2 | 52 | 1 |
| QUETIAPINE | 514 | 0.7% | 2 | 140 | 51 |
| MIRTAZAPINE | 342 | 1.2% | 2 | 91 | 28 |
| PREGABALIN | 329 | 0.3% | 2 | 51 | 7 |
| PRAMIPEXOLE | 326 | 5.4% | 3 | 63 | 3 |
| ARIPIPRAZOLE | 308 | 0.5% | 0 | 52 | 8 |
| ADALIMUMAB | 280 | 0.1% | 1 | 88 | 5 |
| GABAPENTIN | 263 | 0.4% | 1 | 51 | 2 |
| SERTRALINE | 255 | 0.4% | 0 | 50 | 15 |
| ROTIGOTINE | 254 | 3.2% | 2 | 32 | 2 |
| ENZALUTAMIDE | 223 | 0.5% | 9 | 28 | 2 |
| BUROSUMAB-TWZA | 217 | 4.2% | 1 | 4 | 0 |
| VENLAFAXINE | 207 | 0.4% | 3 | 50 | 2 |
| DULOXETINE | 202 | 0.4% | 1 | 16 | 1 |
| CARBIDOPA\LEVODOPA | 198 | 0.3% | 9 | 78 | 2 |
| OXYCODONE | 195 | 0.1% | 8 | 51 | 5 |
| OMEPRAZOLE | 187 | 0.2% | 2 | 55 | 47 |
| TREPROSTINIL | 177 | 0.2% | 6 | 52 | 0 |
| CLONAZEPAM | 174 | 0.4% | 1 | 62 | 35 |
| LENALIDOMIDE | 172 | 0.1% | 2 | 15 | 4 |