Second primary malignancy: Which Medications Cause It? (7,392 Reports Across 237 Drugs)
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Second primary malignancy has been reported as an adverse event with 237 different drugs in the FDA's FAERS database, with 7,392 total reports. 1,825 of these reports resulted in death.The drugs most commonly associated with Second primary malignancy are CYCLOPHOSPHAMIDE, DOXORUBICIN, and VINCRISTINE.
7,392
Total Reports
237
Drugs Involved
1,825
Deaths
1,805
Hospitalizations
59.6 yrs
Average Patient Age
56.2% / 43.8%
Female / Male
Which Drugs Cause Second primary malignancy Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| CYCLOPHOSPHAMIDE | 1,247 | 1.0% | 531 | 242 | 112 |
| DOXORUBICIN | 1,151 | 1.4% | 494 | 210 | 134 |
| VINCRISTINE | 908 | 1.3% | 420 | 158 | 83 |
| IMATINIB | 763 | 1.8% | 171 | 132 | 16 |
| PALBOCICLIB | 658 | 0.7% | 48 | 109 | 10 |
| RITUXIMAB | 646 | 0.4% | 255 | 91 | 64 |
| RUXOLITINIB | 611 | 0.9% | 150 | 159 | 24 |
| ETOPOSIDE | 573 | 1.1% | 248 | 105 | 54 |
| PREDNISONE | 517 | 0.3% | 242 | 97 | 47 |
| OCTREOTIDE | 496 | 2.1% | 125 | 282 | 11 |
| METHOTREXATE | 414 | 0.2% | 169 | 60 | 43 |
| CYTARABINE | 409 | 0.9% | 203 | 98 | 45 |
| CARBOPLATIN | 395 | 0.5% | 113 | 99 | 59 |
| CISPLATIN | 373 | 0.8% | 156 | 84 | 33 |
| NILOTINIB | 337 | 1.5% | 60 | 100 | 13 |
| PACLITAXEL | 317 | 0.4% | 81 | 63 | 42 |
| DEXAMETHASONE | 283 | 0.2% | 123 | 78 | 26 |
| LETROZOLE | 266 | 0.9% | 27 | 71 | 15 |
| LENALIDOMIDE | 244 | 0.1% | 50 | 44 | 26 |
| SUNITINIB MALATE | 244 | 1.1% | 35 | 71 | 11 |