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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Substance abuse: Which Medications Cause It? (6,112 Reports Across 269 Drugs)

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Substance abuse has been reported as an adverse event with 269 different drugs in the FDA's FAERS database, with 6,112 total reports. 1,159 of these reports resulted in death.The drugs most commonly associated with Substance abuse are OXYCODONE, MORPHINE, and COCAINE.

6,112
Total Reports
269
Drugs Involved
1,159
Deaths
1,733
Hospitalizations
36.1 yrs
Average Patient Age
38.6% / 61.4%
Female / Male

Which Drugs Cause Substance abuse Most Often?

Drug Reports % of Drug Reports Deaths Hosp. Life-Threat.
OXYCODONE 1,556 0.8% 499 258 25
MORPHINE 977 0.8% 287 138 12
COCAINE 894 6.3% 277 169 22
BUPRENORPHINE\NALOXONE 798 3.7% 43 142 17
BUPRENORPHINE 694 0.9% 126 223 22
ALCOHOL 611 2.8% 212 110 6
CANNABIS SATIVA SUBSP. INDICA TOP 566 6.6% 83 130 6
DIAZEPAM 555 1.5% 203 129 28
HYDROMORPHONE 547 0.7% 109 102 4
CODEINE 506 2.3% 307 29 11
ALPRAZOLAM 491 1.0% 110 202 28
DIAMORPHINE 484 5.4% 156 87 6
FENTANYL 438 0.5% 175 77 4
PREGABALIN 420 0.4% 72 113 28
CLONAZEPAM 388 1.0% 165 76 14
METHADONE 387 1.5% 151 82 17
ACETAMINOPHEN\OXYCODONE 367 0.4% 86 100 4
QUETIAPINE 344 0.5% 86 151 18
ACETAMINOPHEN\HYDROCODONE 327 0.3% 77 81 8
METHAMPHETAMINE 327 3.8% 72 63 5

View all 269 drugs →

Top 3 Drugs Associated With Substance abuse

1,556 reports
977 reports
894 reports

Related Side Effects

Drug ineffective (1,049,718) Off label use (762,782) Death (660,423) Fatigue (599,248) Nausea (562,301) Diarrhoea (491,550) Pain (471,975) Headache (460,069) Dyspnoea (409,496) Dizziness (352,922)