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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Substance use disorder: Which Medications Cause It? (2,360 Reports Across 118 Drugs)

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Substance use disorder has been reported as an adverse event with 118 different drugs in the FDA's FAERS database, with 2,360 total reports. 149 of these reports resulted in death.The drugs most commonly associated with Substance use disorder are COCAINE, CANNABIS SATIVA SUBSP. INDICA TOP, and DIAZEPAM.

2,360
Total Reports
118
Drugs Involved
149
Deaths
591
Hospitalizations
35.0 yrs
Average Patient Age
30.5% / 69.5%
Female / Male

Which Drugs Cause Substance use disorder Most Often?

Drug Reports % of Drug Reports Deaths Hosp. Life-Threat.
COCAINE 946 6.7% 33 244 138
CANNABIS SATIVA SUBSP. INDICA TOP 790 9.1% 32 218 99
DIAZEPAM 547 1.4% 15 135 103
OXYCODONE 527 0.3% 74 51 8
TRAMADOL 469 0.6% 33 78 24
PREGABALIN 436 0.4% 0 129 43
MORPHINE 386 0.3% 44 69 18
BUPRENORPHINE 323 0.4% 47 51 33
ALCOHOL 318 1.5% 8 90 38
ACETAMINOPHEN\OXYCODONE 305 0.3% 36 19 3
HYDROMORPHONE 289 0.4% 33 21 4
ACETAMINOPHEN\HYDROCODONE 270 0.3% 36 24 6
CLONAZEPAM 235 0.6% 5 67 36
METHADONE 196 0.8% 12 52 30
ALPRAZOLAM 181 0.4% 10 71 9
OXAZEPAM 155 1.3% 0 30 38
BROMAZEPAM 140 2.2% 6 51 14
FENTANYL 133 0.1% 21 26 4
DIAMORPHINE 128 1.4% 10 15 11
QUETIAPINE 124 0.2% 2 44 9

View all 118 drugs →

Top 3 Drugs Associated With Substance use disorder

946 reports
547 reports

Related Side Effects

Drug ineffective (1,049,718) Off label use (762,782) Death (660,423) Fatigue (599,248) Nausea (562,301) Diarrhoea (491,550) Pain (471,975) Headache (460,069) Dyspnoea (409,496) Dizziness (352,922)