Torsade de pointes: Which Medications Cause It? (4,825 Reports Across 324 Drugs)
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Torsade de pointes has been reported as an adverse event with 324 different drugs in the FDA's FAERS database, with 4,825 total reports. 399 of these reports resulted in death.The drugs most commonly associated with Torsade de pointes are AMIODARONE, LOPERAMIDE, and ONDANSETRON.
4,825
Total Reports
324
Drugs Involved
399
Deaths
3,065
Hospitalizations
55.4 yrs
Average Patient Age
63.3% / 36.7%
Female / Male
Which Drugs Cause Torsade de pointes Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| AMIODARONE | 522 | 2.1% | 25 | 314 | 254 |
| LOPERAMIDE | 366 | 2.0% | 22 | 311 | 213 |
| ONDANSETRON | 331 | 1.5% | 26 | 228 | 191 |
| FUROSEMIDE | 305 | 0.6% | 14 | 190 | 136 |
| METHADONE | 240 | 0.9% | 9 | 148 | 59 |
| CITALOPRAM HYDROBROMIDE | 182 | 0.7% | 34 | 103 | 48 |
| QUETIAPINE | 172 | 0.2% | 4 | 121 | 79 |
| OLANZAPINE | 171 | 0.3% | 39 | 100 | 72 |
| HYDROXYCHLOROQUINE | 167 | 0.3% | 12 | 119 | 49 |
| FLUOXETINE | 164 | 0.5% | 2 | 125 | 87 |
| CIPROFLOXACIN | 149 | 0.3% | 9 | 103 | 64 |
| ESCITALOPRAM OXALATE | 148 | 0.5% | 12 | 88 | 66 |
| SOTALOL | 145 | 3.9% | 20 | 80 | 45 |
| LEVOFLOXACIN | 144 | 0.4% | 26 | 88 | 78 |
| HALOPERIDOL | 136 | 0.9% | 38 | 98 | 67 |
| METOPROLOL | 133 | 0.3% | 1 | 86 | 48 |
| FLUCONAZOLE | 121 | 0.8% | 5 | 83 | 71 |
| DIGOXIN | 109 | 1.4% | 12 | 88 | 48 |
| METOCLOPRAMIDE | 106 | 1.0% | 5 | 62 | 42 |
| AZITHROMYCIN ANHYDROUS | 105 | 0.7% | 11 | 58 | 41 |