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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Type iv hypersensitivity reaction: Which Medications Cause It? (2,097 Reports Across 181 Drugs)

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Type iv hypersensitivity reaction has been reported as an adverse event with 181 different drugs in the FDA's FAERS database, with 2,097 total reports. 36 of these reports resulted in death.The drugs most commonly associated with Type iv hypersensitivity reaction are AMOXICILLIN, CLINDAMYCIN, and INFLIXIMAB.

2,097
Total Reports
181
Drugs Involved
36
Deaths
653
Hospitalizations
49.5 yrs
Average Patient Age
61.4% / 38.6%
Female / Male

Which Drugs Cause Type iv hypersensitivity reaction Most Often?

Drug Reports % of Drug Reports Deaths Hosp. Life-Threat.
AMOXICILLIN 165 0.6% 0 39 6
CLINDAMYCIN 128 0.8% 0 10 0
INFLIXIMAB 120 0.1% 2 55 6
CEFACLOR 101 9.6% 0 0 0
IBUPROFEN 98 0.1% 0 54 8
AMPICILLIN 97 2.7% 0 1 0
VANCOMYCIN 97 0.3% 2 39 14
CEPHALEXIN 92 1.2% 0 4 0
AMOXICILLIN\CLAVULANIC ACID 89 0.8% 0 16 4
CEFUROXIME 82 1.6% 0 0 0
CEFADROXIL 53 9.9% 0 0 0
RIFAMPIN 51 0.4% 1 4 0
MEROPENEM 45 0.3% 0 13 6
METRONIDAZOLE 45 0.2% 0 23 1
ADALIMUMAB 44 0.0% 0 20 0
AMOXICILLIN\CLAVULANATE 44 0.3% 0 11 2
CARBOPLATIN 44 0.1% 2 19 5
SULFAMETHOXAZOLE\TRIMETHOPRIM 42 0.1% 0 28 6
METHOTREXATE 40 0.0% 0 20 1
CIPROFLOXACIN 39 0.1% 0 18 1

View all 181 drugs →

Top 3 Drugs Associated With Type iv hypersensitivity reaction

165 reports
128 reports
120 reports

Related Side Effects

Drug ineffective (1,049,718) Off label use (762,782) Death (660,423) Fatigue (599,248) Nausea (562,301) Diarrhoea (491,550) Pain (471,975) Headache (460,069) Dyspnoea (409,496) Dizziness (352,922)