Withdrawal syndrome: Which Medications Cause It? (32,730 Reports Across 580 Drugs)
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Withdrawal syndrome has been reported as an adverse event with 580 different drugs in the FDA's FAERS database, with 32,730 total reports. 1,075 of these reports resulted in death.The drugs most commonly associated with Withdrawal syndrome are ACETAMINOPHEN\OXYCODONE, PREGABALIN, and OXYCODONE.
32,730
Total Reports
580
Drugs Involved
1,075
Deaths
6,186
Hospitalizations
47.6 yrs
Average Patient Age
59.5% / 40.5%
Female / Male
Which Drugs Cause Withdrawal syndrome Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| ACETAMINOPHEN\OXYCODONE | 4,046 | 4.1% | 239 | 171 | 13 |
| PREGABALIN | 3,329 | 3.3% | 14 | 719 | 75 |
| OXYCODONE | 2,798 | 1.5% | 471 | 421 | 36 |
| ACETAMINOPHEN\HYDROCODONE | 2,636 | 2.4% | 158 | 191 | 17 |
| FENTANYL | 1,948 | 2.1% | 68 | 271 | 30 |
| MORPHINE | 1,674 | 1.4% | 165 | 312 | 22 |
| TRAMADOL | 1,582 | 2.1% | 73 | 377 | 23 |
| VENLAFAXINE | 1,516 | 3.2% | 23 | 271 | 129 |
| DULOXETINE | 1,328 | 2.5% | 19 | 191 | 102 |
| BUPRENORPHINE | 1,266 | 1.5% | 52 | 227 | 18 |
| HYDROMORPHONE | 1,040 | 1.3% | 158 | 224 | 13 |
| CLONAZEPAM | 980 | 2.5% | 16 | 265 | 86 |
| CETIRIZINE | 935 | 2.0% | 0 | 6 | 1 |
| SERTRALINE | 914 | 1.5% | 7 | 249 | 72 |
| ALPRAZOLAM | 876 | 1.8% | 34 | 391 | 67 |
| BACLOFEN | 786 | 3.1% | 13 | 354 | 61 |
| OXYMORPHONE | 757 | 2.0% | 46 | 30 | 3 |
| GABAPENTIN | 751 | 1.0% | 22 | 299 | 61 |
| PAROXETINE | 603 | 2.8% | 34 | 164 | 46 |
| QUETIAPINE | 600 | 0.8% | 22 | 273 | 67 |