Cytochrome P450 3A4 Inducers [MoA]: Side Effects & Safety Data for 21 Drugs
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Cytochrome P450 3A4 Inducers [MoA] includes 21 drugs with a combined 195,439 adverse event reports in the FDA FAERS database. Compare their safety profiles, side effects, and outcomes below.
21
Drugs in Class
195,439
Combined Reports
All Cytochrome P450 3A4 Inducers [MoA] Drugs Ranked by Reports
| Drug | Brand Name | Reports | Deaths | Hosp. | Death Rate |
|---|---|---|---|---|---|
| ENZALUTAMIDE | Xtandi | 49,270 | 9,676 | 9,282 | 19.6% |
| TOPIRAMATE | Topiramate | 28,609 | 3,527 | 7,098 | 12.3% |
| OSIMERTINIB | TAGRISSO | 27,750 | 12,456 | 5,277 | 44.9% |
| CARBAMAZEPINE | Carbamazepine | 24,577 | 2,156 | 9,608 | 8.8% |
| DABRAFENIB | Tafinlar | 19,305 | 4,165 | 5,325 | 21.6% |
| DEFERASIROX | Deferasirox | 11,322 | 2,661 | 4,008 | 23.5% |
| CLOBAZAM | Clobazam | 10,596 | 725 | 3,312 | 6.8% |
| CENOBAMATE | Xcopri | 5,643 | 125 | 1,012 | 2.2% |
| APREPITANT | CINVANTI | 5,620 | 1,195 | 2,917 | 21.3% |
| ESLICARBAZEPINE | Eslicarbazepine Acetate | 3,127 | 97 | 750 | 3.1% |
| IVOSIDENIB | TIBSOVO | 1,695 | 121 | 505 | 7.1% |
| OMAVELOXOLONE | SKYCLARYS | 1,249 | 54 | 304 | 4.3% |
| ERDAFITINIB | BALVERSA | 1,106 | 315 | 226 | 28.5% |
| BELZUTIFAN | WELIREG | 1,021 | 82 | 550 | 8.0% |
| MITOTANE | Lysodren | 1,011 | 88 | 245 | 8.7% |
| FOSAPREPITANT DIMEGLUMINE | Fosaprepitant | 888 | 118 | 364 | 13.3% |
| ORITAVANCIN | Orbactiv | 884 | 29 | 157 | 3.3% |
| PITOLISANT | Wakix | 843 | 7 | 70 | 0.8% |
| FOSAMPRENAVIR | Fosamprenavir Calcium | 460 | 31 | 91 | 6.7% |
| ORITAVANCIN DIPHOSPHATE | Kimyrsa | 276 | 4 | 27 | 1.4% |
| REPOTRECTINIB | Augtyro | 187 | 27 | 48 | 14.4% |
Common Side Effects in Cytochrome P450 3A4 Inducers [MoA] Drugs
| Side Effect | Reports | Deaths |
|---|---|---|
| Death | 22,766 | 22,730 |
| Fatigue | 16,463 | 1,759 |
| Drug ineffective | 16,437 | 1,622 |
| Off label use | 10,803 | 1,812 |
| Nausea | 9,867 | 1,330 |
| Malignant neoplasm progression | 9,558 | 2,869 |
| Seizure | 9,055 | 311 |
| Diarrhoea | 8,348 | 1,391 |
| Pyrexia | 7,763 | 1,158 |
| Dizziness | 7,587 | 1,007 |