Cytochrome P450 3A4 Inducers [MoA] — Common Side Effects
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| Side Effect | Total Reports | Drugs | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| Death | 22,766 | 19 | 22,730 | 1,486 | 130 |
| Fatigue | 16,463 | 18 | 1,759 | 3,865 | 1,098 |
| Drug ineffective | 16,437 | 19 | 1,622 | 3,959 | 1,396 |
| Off label use | 10,803 | 20 | 1,812 | 3,674 | 1,614 |
| Nausea | 9,867 | 21 | 1,330 | 3,384 | 825 |
| Malignant neoplasm progression | 9,558 | 12 | 2,869 | 1,644 | 189 |
| Seizure | 9,055 | 17 | 311 | 2,600 | 363 |
| Diarrhoea | 8,348 | 19 | 1,391 | 2,977 | 938 |
| Pyrexia | 7,763 | 19 | 1,158 | 4,455 | 928 |
| Dizziness | 7,587 | 21 | 1,007 | 2,313 | 829 |
| Asthenia | 7,258 | 19 | 1,418 | 2,751 | 819 |
| Headache | 6,695 | 19 | 925 | 2,156 | 890 |
| Decreased appetite | 6,613 | 17 | 1,242 | 2,505 | 682 |
| Vomiting | 6,418 | 20 | 1,325 | 3,429 | 1,097 |
| Rash | 6,323 | 20 | 1,273 | 2,642 | 1,203 |
| Pain | 5,812 | 21 | 1,150 | 2,901 | 1,034 |
| Dyspnoea | 5,329 | 21 | 1,112 | 2,766 | 954 |
| Fall | 5,198 | 15 | 707 | 2,978 | 491 |
| Malaise | 5,018 | 18 | 1,192 | 2,351 | 837 |
| Somnolence | 4,937 | 16 | 230 | 1,493 | 218 |
| Arthralgia | 4,462 | 20 | 968 | 1,692 | 851 |
| Product use in unapproved indication | 4,378 | 15 | 962 | 1,638 | 906 |
| Weight decreased | 4,348 | 17 | 633 | 1,493 | 431 |
| Insomnia | 3,906 | 15 | 867 | 1,420 | 838 |
| Constipation | 3,784 | 18 | 258 | 1,464 | 133 |
| Confusional state | 3,774 | 17 | 1,092 | 2,130 | 996 |
| Condition aggravated | 3,765 | 16 | 1,110 | 2,116 | 1,069 |
| Toxicity to various agents | 3,752 | 11 | 1,467 | 2,042 | 460 |
| Prostatic specific antigen increased | 3,731 | 1 | 321 | 463 | 22 |
| Pneumonia | 3,525 | 17 | 1,459 | 2,663 | 826 |