Cytochrome P450 3A4 Inhibitors [MoA]: Side Effects & Safety Data for 35 Drugs
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Cytochrome P450 3A4 Inhibitors [MoA] includes 35 drugs with a combined 392,924 adverse event reports in the FDA FAERS database. Compare their safety profiles, side effects, and outcomes below.
35
Drugs in Class
392,924
Combined Reports
All Cytochrome P450 3A4 Inhibitors [MoA] Drugs Ranked by Reports
| Drug | Brand Name | Reports | Deaths | Hosp. | Death Rate |
|---|---|---|---|---|---|
| CYCLOSPORINE | Verkazia | 68,304 | 9,332 | 14,257 | 13.7% |
| IMATINIB | Imatinib | 43,161 | 13,761 | 7,264 | 31.9% |
| EVEROLIMUS | EVEROLIMUS | 39,640 | 8,374 | 11,211 | 21.1% |
| DASATINIB | dasatinib | 30,019 | 2,681 | 6,437 | 8.9% |
| TICAGRELOR | Ticagrelor | 22,885 | 2,951 | 8,579 | 12.9% |
| VOXELOTOR | OXBRYTA | 21,940 | 396 | 7,660 | 1.8% |
| PAZOPANIB | Pazopanib | 21,208 | 5,612 | 4,347 | 26.5% |
| CLARITHROMYCIN | Clarithromycin | 18,945 | 987 | 6,385 | 5.2% |
| FLUCONAZOLE | Fluconazole | 15,157 | 2,546 | 5,821 | 16.8% |
| DILTIAZEM | Cardizem CD | 14,726 | 4,562 | 6,674 | 31.0% |
| VORICONAZOLE | Voriconazole | 14,384 | 3,940 | 5,118 | 27.4% |
| RITONAVIR | Norvir | 11,980 | 1,190 | 2,925 | 9.9% |
| VERAPAMIL | Verapamil Hydrochloride | 9,320 | 2,630 | 3,576 | 28.2% |
| EFAVIRENZ | Efavirenz, Emtricitabine and Tenofovir Disoproxil Fumarate | 7,893 | 962 | 1,528 | 12.2% |
| APREPITANT | CINVANTI | 5,620 | 1,195 | 2,917 | 21.3% |
| KETOCONAZOLE | Ketoconazole | 5,571 | 132 | 330 | 2.4% |
| ATAZANAVIR | Atazanavir Sulfate | 5,434 | 425 | 1,112 | 7.8% |
| TROFINETIDE | Daybue | 4,764 | 27 | 581 | 0.6% |
| AVACOPAN | TAVNEOS | 4,464 | 446 | 1,577 | 10.0% |
| PERAMPANEL | Fycompa | 4,446 | 249 | 1,760 | 5.6% |
| ITRACONAZOLE | Itraconazole | 4,009 | 504 | 1,343 | 12.6% |
| LOMITAPIDE | Juxtapid | 3,779 | 109 | 434 | 2.9% |
| PACRITINIB | Vonjo | 2,563 | 292 | 455 | 11.4% |
| NICARDIPINE | NICARDIPINE HYDROCHLORIDE | 2,317 | 182 | 1,073 | 7.9% |
| ISAVUCONAZONIUM | CRESEMBA | 2,065 | 413 | 425 | 20.0% |
| MARIBAVIR | Livtencity | 1,923 | 386 | 893 | 20.1% |
| OSILODROSTAT | Isturisa | 1,626 | 191 | 526 | 11.7% |
| ERDAFITINIB | BALVERSA | 1,106 | 315 | 226 | 28.5% |
| FOSAPREPITANT DIMEGLUMINE | Fosaprepitant | 888 | 118 | 364 | 13.3% |
| VILOXAZINE | QELBREE | 853 | 9 | 59 | 1.1% |
| BEROTRALSTAT | Orladeyo | 548 | 24 | 128 | 4.4% |
| FOSAMPRENAVIR | Fosamprenavir Calcium | 460 | 31 | 91 | 6.7% |
| LAZERTINIB | LAZCLUZE | 352 | 15 | 83 | 4.3% |
| LEVOKETOCONAZOLE | Recorlev | 309 | 8 | 99 | 2.6% |
| GIVINOSTAT | DUVYZAT | 265 | 5 | 17 | 1.9% |
Common Side Effects in Cytochrome P450 3A4 Inhibitors [MoA] Drugs
| Side Effect | Reports | Deaths |
|---|---|---|
| Drug ineffective | 33,154 | 5,212 |
| Death | 27,867 | 27,778 |
| Diarrhoea | 24,873 | 2,590 |
| Off label use | 23,584 | 3,434 |
| Nausea | 19,830 | 1,936 |
| Fatigue | 18,490 | 2,238 |
| Dyspnoea | 15,396 | 2,756 |
| Headache | 13,565 | 1,707 |
| Vomiting | 12,539 | 2,085 |
| Pyrexia | 11,727 | 2,682 |