Protein Kinase Inhibitors [MoA]: Side Effects & Safety Data for 18 Drugs
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Protein Kinase Inhibitors [MoA] includes 18 drugs with a combined 341,716 adverse event reports in the FDA FAERS database. Compare their safety profiles, side effects, and outcomes below.
18
Drugs in Class
341,716
Combined Reports
All Protein Kinase Inhibitors [MoA] Drugs Ranked by Reports
| Drug | Brand Name | Reports | Deaths | Hosp. | Death Rate |
|---|---|---|---|---|---|
| IBRUTINIB | Imbruvica | 75,087 | 12,580 | 24,920 | 16.8% |
| EVEROLIMUS | EVEROLIMUS | 39,640 | 8,374 | 11,211 | 21.1% |
| CABOZANTINIB S-MALATE | CABOMETYX | 39,270 | 4,203 | 6,193 | 10.7% |
| DASATINIB | dasatinib | 30,019 | 2,681 | 6,437 | 8.9% |
| ERLOTINIB | Erlotinib | 22,472 | 6,791 | 3,693 | 30.2% |
| SUNITINIB MALATE | Sunitinib malate | 21,578 | 6,028 | 5,720 | 27.9% |
| PAZOPANIB | Pazopanib | 21,208 | 5,612 | 4,347 | 26.5% |
| DABRAFENIB | Tafinlar | 19,305 | 4,165 | 5,325 | 21.6% |
| TRAMETINIB DIMETHYL SULFOXIDE | Mekinist | 16,286 | 3,925 | 3,438 | 24.1% |
| SIROLIMUS | sirolimus | 11,371 | 1,737 | 3,535 | 15.3% |
| SORAFENIB | sorafenib | 10,908 | 2,489 | 3,547 | 22.8% |
| PONATINIB | Iclusig | 10,011 | 2,924 | 4,254 | 29.2% |
| VEMURAFENIB | ZELBORAF | 8,562 | 1,040 | 2,368 | 12.1% |
| AFATINIB | Gilotrif | 6,078 | 1,346 | 2,055 | 22.1% |
| GEFITINIB | Gefitinib | 4,697 | 1,047 | 853 | 22.3% |
| LAPATINIB DITOSYLATE | Lapatinib | 3,948 | 921 | 752 | 23.3% |
| VANDETANIB | CAPRELSA | 1,159 | 93 | 363 | 8.0% |
| NINTEDANIB ESYLATE | Ofev | 117 | 23 | 39 | 19.7% |
Common Side Effects in Protein Kinase Inhibitors [MoA] Drugs
| Side Effect | Reports | Deaths |
|---|---|---|
| Death | 41,513 | 41,428 |
| Diarrhoea | 34,613 | 3,170 |
| Fatigue | 28,712 | 2,423 |
| Off label use | 21,593 | 3,820 |
| Nausea | 20,944 | 1,984 |
| Rash | 18,564 | 1,601 |
| Malignant neoplasm progression | 16,760 | 5,457 |
| Pyrexia | 14,428 | 1,814 |
| Decreased appetite | 14,321 | 1,961 |
| Vomiting | 12,162 | 1,630 |