Protein Kinase Inhibitors [MoA] — Common Side Effects
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| Side Effect | Total Reports | Drugs | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| Death | 41,513 | 18 | 41,428 | 4,088 | 217 |
| Diarrhoea | 34,613 | 18 | 3,170 | 9,454 | 672 |
| Fatigue | 28,712 | 18 | 2,423 | 6,823 | 395 |
| Off label use | 21,593 | 18 | 3,820 | 5,304 | 545 |
| Nausea | 20,944 | 18 | 1,984 | 6,100 | 406 |
| Rash | 18,564 | 17 | 1,601 | 3,654 | 264 |
| Malignant neoplasm progression | 16,760 | 18 | 5,457 | 3,970 | 536 |
| Pyrexia | 14,428 | 18 | 1,814 | 7,394 | 729 |
| Decreased appetite | 14,321 | 18 | 1,961 | 4,680 | 333 |
| Vomiting | 12,162 | 18 | 1,630 | 5,284 | 425 |
| Asthenia | 11,990 | 18 | 2,072 | 5,159 | 318 |
| Drug ineffective | 11,009 | 17 | 1,499 | 2,062 | 454 |
| Weight decreased | 10,207 | 18 | 1,205 | 3,316 | 217 |
| Dyspnoea | 9,690 | 18 | 1,908 | 4,867 | 416 |
| Malaise | 9,587 | 18 | 1,409 | 3,443 | 284 |
| Headache | 9,460 | 18 | 687 | 2,639 | 152 |
| Stomatitis | 9,170 | 17 | 675 | 2,155 | 165 |
| Disease progression | 9,134 | 17 | 2,561 | 1,787 | 156 |
| Pain | 8,777 | 18 | 1,040 | 2,972 | 281 |
| Pneumonia | 8,626 | 17 | 2,270 | 5,918 | 677 |
| Hypertension | 7,824 | 17 | 750 | 2,489 | 227 |
| Arthralgia | 7,527 | 17 | 490 | 1,855 | 106 |
| Constipation | 7,144 | 18 | 749 | 2,234 | 98 |
| Pain in extremity | 6,860 | 17 | 501 | 1,856 | 93 |
| Blood pressure increased | 6,842 | 18 | 380 | 1,756 | 83 |
| Pleural effusion | 6,478 | 17 | 1,100 | 3,446 | 393 |
| Dizziness | 6,462 | 18 | 567 | 2,301 | 149 |
| Cough | 6,193 | 18 | 807 | 2,321 | 177 |
| Anaemia | 6,141 | 17 | 1,201 | 2,946 | 397 |
| Product use in unapproved indication | 6,102 | 17 | 1,108 | 1,297 | 237 |