Sphingosine 1-Phosphate Receptor Modulators [MoA] — Common Side Effects
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| Side Effect | Total Reports | Drugs | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| Fatigue | 10,666 | 6 | 38 | 1,077 | 133 |
| Multiple sclerosis relapse | 7,817 | 5 | 57 | 1,972 | 137 |
| Headache | 7,451 | 6 | 30 | 864 | 124 |
| Dizziness | 5,393 | 6 | 19 | 724 | 75 |
| White blood cell count decreased | 3,971 | 4 | 15 | 348 | 52 |
| Lymphocyte count decreased | 3,745 | 4 | 33 | 587 | 78 |
| Drug ineffective | 3,736 | 5 | 19 | 356 | 51 |
| Gait disturbance | 3,636 | 4 | 25 | 868 | 86 |
| Hypoaesthesia | 3,634 | 5 | 14 | 732 | 69 |
| Fall | 3,364 | 4 | 25 | 913 | 66 |
| Nausea | 3,170 | 6 | 21 | 503 | 76 |
| Malaise | 3,036 | 4 | 26 | 614 | 94 |
| Memory impairment | 3,023 | 3 | 9 | 348 | 49 |
| Pain | 2,953 | 5 | 18 | 555 | 74 |
| Multiple sclerosis | 2,749 | 4 | 64 | 481 | 38 |
| Asthenia | 2,707 | 5 | 35 | 692 | 82 |
| Pain in extremity | 2,567 | 3 | 14 | 466 | 48 |
| Central nervous system lesion | 2,557 | 4 | 23 | 447 | 49 |
| Visual impairment | 2,522 | 4 | 12 | 400 | 49 |
| Heart rate decreased | 2,514 | 5 | 7 | 262 | 25 |
| Depression | 2,426 | 3 | 22 | 319 | 58 |
| Vision blurred | 2,357 | 5 | 8 | 337 | 36 |
| Back pain | 2,313 | 4 | 10 | 351 | 37 |
| Feeling abnormal | 2,304 | 4 | 12 | 307 | 132 |
| Balance disorder | 2,260 | 3 | 4 | 417 | 34 |
| Paraesthesia | 2,233 | 4 | 6 | 379 | 37 |
| Muscular weakness | 2,069 | 4 | 16 | 562 | 50 |
| Diarrhoea | 2,044 | 4 | 13 | 285 | 26 |
| Dyspnoea | 2,016 | 5 | 46 | 484 | 97 |
| Nasopharyngitis | 2,009 | 4 | 4 | 155 | 20 |