Does ALLOPURINOL Cause Agranulocytosis? 209 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 209 reports of Agranulocytosis have been filed in association with ALLOPURINOL (Allopurinol). This represents 1.1% of all adverse event reports for ALLOPURINOL.
209
Reports of Agranulocytosis with ALLOPURINOL
1.1%
of all ALLOPURINOL reports
24
Deaths
160
Hospitalizations
How Dangerous Is Agranulocytosis From ALLOPURINOL?
Of the 209 reports, 24 (11.5%) resulted in death, 160 (76.6%) required hospitalization, and 35 (16.7%) were considered life-threatening.
Is Agranulocytosis Listed in the Official Label?
Yes, Agranulocytosis is listed as a known adverse reaction in the official FDA drug label for ALLOPURINOL.
What Other Side Effects Does ALLOPURINOL Cause?
Drug reaction with eosinophilia and systemic symptoms (2,943)
Acute kidney injury (1,583)
Rash (1,103)
Off label use (921)
Pyrexia (913)
Dyspnoea (905)
Toxic epidermal necrolysis (858)
Pruritus (836)
Diarrhoea (819)
Drug ineffective (780)
What Other Drugs Cause Agranulocytosis?
CLOZAPINE (1,766)
CYCLOPHOSPHAMIDE (1,242)
RITUXIMAB (1,154)
SULFAMETHOXAZOLE\TRIMETHOPRIM (797)
PANTOPRAZOLE (599)
METHOTREXATE (550)
SODIUM (549)
EPIRUBICIN (491)
METAMIZOLE (438)
DOCETAXEL (436)
Which ALLOPURINOL Alternatives Have Lower Agranulocytosis Risk?
ALLOPURINOL vs ALMOTRIPTAN
ALLOPURINOL vs ALMOTRIPTAN MALATE
ALLOPURINOL vs ALOE VERA LEAF
ALLOPURINOL vs ALOGLIPTIN
ALLOPURINOL vs ALOGLIPTIN\METFORMIN