Does ASPARAGINASE Cause Osteonecrosis? 148 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 148 reports of Osteonecrosis have been filed in association with ASPARAGINASE (Rylaze). This represents 3.0% of all adverse event reports for ASPARAGINASE.
148
Reports of Osteonecrosis with ASPARAGINASE
3.0%
of all ASPARAGINASE reports
3
Deaths
11
Hospitalizations
How Dangerous Is Osteonecrosis From ASPARAGINASE?
Of the 148 reports, 3 (2.0%) resulted in death, 11 (7.4%) required hospitalization, and 1 (0.7%) were considered life-threatening.
Is Osteonecrosis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for ASPARAGINASE. However, 148 reports have been filed with the FAERS database.
What Other Side Effects Does ASPARAGINASE Cause?
Febrile neutropenia (557)
Neutropenia (322)
Bacterial infection (295)
Off label use (267)
Secondary immunodeficiency (233)
Viral infection (228)
Clostridium difficile colitis (213)
Pyrexia (204)
Sepsis (200)
Pneumonia (196)
What Other Drugs Cause Osteonecrosis?
EMTRICITABINE\TENOFOVIR DISOPROXIL (8,935)
TENOFOVIR DISOPROXIL (7,182)
EFAVIRENZ\EMTRICITABINE\TENOFOVIR DISOPROXIL (4,338)
COBICISTAT\ELVITEGRAVIR\EMTRICITABINE\TENOFOVIR DISOPROXIL (2,081)
EMTRICITABINE\RILPIVIRINE\TENOFOVIR DISOPROXIL (1,492)
PREDNISONE (779)
PREDNISOLONE (711)
DENOSUMAB (567)
METHOTREXATE (563)
DEXAMETHASONE (531)
Which ASPARAGINASE Alternatives Have Lower Osteonecrosis Risk?
ASPARAGINASE vs ASPARAGINASE ERWINIA CHRYSANTHEMI
ASPARAGINASE vs ASPARAGINASE ERWINIA CHRYSANTHEMI -RYWN
ASPARAGINASE vs ASPIRIN
ASPARAGINASE vs ASPIRIN DL-LYSINE
ASPARAGINASE vs ASPIRIN LYSINE