Does COBIMETINIB Cause Hepatotoxicity? 28 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 28 reports of Hepatotoxicity have been filed in association with COBIMETINIB (Cotellic). This represents 0.7% of all adverse event reports for COBIMETINIB.
28
Reports of Hepatotoxicity with COBIMETINIB
0.7%
of all COBIMETINIB reports
1
Deaths
7
Hospitalizations
How Dangerous Is Hepatotoxicity From COBIMETINIB?
Of the 28 reports, 1 (3.6%) resulted in death, 7 (25.0%) required hospitalization, and 2 (7.1%) were considered life-threatening.
Is Hepatotoxicity Listed in the Official Label?
Yes, Hepatotoxicity is listed as a known adverse reaction in the official FDA drug label for COBIMETINIB.
What Other Side Effects Does COBIMETINIB Cause?
Diarrhoea (412)
Off label use (411)
Rash (369)
Pyrexia (332)
Death (231)
Nausea (206)
Fatigue (198)
No adverse event (178)
Vomiting (168)
Acute kidney injury (133)
What Other Drugs Cause Hepatotoxicity?
METHOTREXATE (1,917)
ACETAMINOPHEN (1,557)
LEFLUNOMIDE (829)
HYDROXYCHLOROQUINE (715)
PREDNISONE (707)
RITUXIMAB (702)
ETANERCEPT (699)
ADALIMUMAB (674)
CYCLOPHOSPHAMIDE (632)
SULFASALAZINE (613)
Which COBIMETINIB Alternatives Have Lower Hepatotoxicity Risk?
COBIMETINIB vs COCAETHYLENE
COBIMETINIB vs COCAINE
COBIMETINIB vs COCOA BUTTER\PHENYLEPHRINE
COBIMETINIB vs COD LIVER OIL
COBIMETINIB vs CODEINE