Does DIVALPROEX Cause Hyperammonaemia? 256 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 256 reports of Hyperammonaemia have been filed in association with DIVALPROEX (Divalproex Sodium). This represents 2.2% of all adverse event reports for DIVALPROEX.
256
Reports of Hyperammonaemia with DIVALPROEX
2.2%
of all DIVALPROEX reports
4
Deaths
195
Hospitalizations
How Dangerous Is Hyperammonaemia From DIVALPROEX?
Of the 256 reports, 4 (1.6%) resulted in death, 195 (76.2%) required hospitalization, and 42 (16.4%) were considered life-threatening.
Is Hyperammonaemia Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for DIVALPROEX. However, 256 reports have been filed with the FAERS database.
What Other Side Effects Does DIVALPROEX Cause?
Drug ineffective (1,121)
Seizure (1,095)
Off label use (576)
Somnolence (545)
Drug interaction (540)
Nausea (526)
Weight increased (509)
Tremor (461)
Toxicity to various agents (452)
Vomiting (436)
What Other Drugs Cause Hyperammonaemia?
VALPROIC ACID (581)
VALPROATE (328)
FLUOROURACIL (263)
LEVETIRACETAM (192)
TACROLIMUS (181)
ACETAMINOPHEN (177)
OXALIPLATIN (160)
TOPIRAMATE (156)
GLYCEROL PHENYLBUTYRATE (147)
METHOTREXATE (126)
Which DIVALPROEX Alternatives Have Lower Hyperammonaemia Risk?
DIVALPROEX vs DOBUTAMINE
DIVALPROEX vs DOBUTAMINE\DOBUTAMINE
DIVALPROEX vs DOCETAXEL
DIVALPROEX vs DOCETAXEL ANHYDROUS
DIVALPROEX vs DOCETAXEL\DOCETAXEL ANHYDROUS