Hyperammonaemia: Which Medications Cause It? (3,484 Reports Across 237 Drugs)
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Hyperammonaemia has been reported as an adverse event with 237 different drugs in the FDA's FAERS database, with 3,484 total reports. 503 of these reports resulted in death.The drugs most commonly associated with Hyperammonaemia are VALPROIC ACID, VALPROATE, and FLUOROURACIL.
3,484
Total Reports
237
Drugs Involved
503
Deaths
2,355
Hospitalizations
43.3 yrs
Average Patient Age
45.6% / 54.4%
Female / Male
Which Drugs Cause Hyperammonaemia Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| VALPROIC ACID | 581 | 2.9% | 26 | 385 | 96 |
| VALPROATE | 328 | 2.1% | 14 | 198 | 25 |
| FLUOROURACIL | 263 | 0.5% | 12 | 133 | 54 |
| DIVALPROEX | 256 | 2.2% | 4 | 195 | 42 |
| LEVETIRACETAM | 192 | 0.3% | 18 | 67 | 18 |
| TACROLIMUS | 181 | 0.2% | 100 | 117 | 74 |
| ACETAMINOPHEN | 177 | 0.1% | 17 | 169 | 23 |
| OXALIPLATIN | 160 | 0.3% | 8 | 84 | 35 |
| TOPIRAMATE | 156 | 0.6% | 0 | 84 | 1 |
| GLYCEROL PHENYLBUTYRATE | 147 | 11.7% | 3 | 119 | 5 |
| METHOTREXATE | 126 | 0.1% | 48 | 100 | 45 |
| PREDNISONE | 112 | 0.1% | 64 | 90 | 60 |
| METHYLPREDNISOLONE | 109 | 0.2% | 52 | 73 | 41 |
| OLANZAPINE | 107 | 0.2% | 5 | 73 | 24 |
| MYCOPHENOLATE MOFETIL | 102 | 0.1% | 72 | 75 | 52 |
| QUETIAPINE | 102 | 0.1% | 4 | 86 | 29 |
| PHENYTOIN | 95 | 0.7% | 2 | 40 | 8 |
| CLOBAZAM | 92 | 0.9% | 1 | 32 | 7 |
| LAMOTRIGINE | 90 | 0.2% | 0 | 25 | 5 |
| CARBAMAZEPINE | 89 | 0.4% | 0 | 54 | 2 |