Does LAMOTRIGINE Cause Hyperammonaemia? 90 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 90 reports of Hyperammonaemia have been filed in association with LAMOTRIGINE (Lamotrigine ER). This represents 0.2% of all adverse event reports for LAMOTRIGINE.
90
Reports of Hyperammonaemia with LAMOTRIGINE
0.2%
of all LAMOTRIGINE reports
0
Deaths
25
Hospitalizations
How Dangerous Is Hyperammonaemia From LAMOTRIGINE?
Of the 90 reports, 25 (27.8%) required hospitalization, and 5 (5.6%) were considered life-threatening.
Is Hyperammonaemia Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for LAMOTRIGINE. However, 90 reports have been filed with the FAERS database.
What Other Side Effects Does LAMOTRIGINE Cause?
Drug ineffective (5,175)
Seizure (3,459)
Toxicity to various agents (3,256)
Rash (3,249)
Foetal exposure during pregnancy (2,985)
Off label use (2,625)
Completed suicide (2,433)
Drug reaction with eosinophilia and systemic symptoms (2,235)
Dizziness (2,170)
Pyrexia (1,967)
What Other Drugs Cause Hyperammonaemia?
VALPROIC ACID (581)
VALPROATE (328)
FLUOROURACIL (263)
DIVALPROEX (256)
LEVETIRACETAM (192)
TACROLIMUS (181)
ACETAMINOPHEN (177)
OXALIPLATIN (160)
TOPIRAMATE (156)
GLYCEROL PHENYLBUTYRATE (147)
Which LAMOTRIGINE Alternatives Have Lower Hyperammonaemia Risk?
LAMOTRIGINE vs LANADELUMAB
LAMOTRIGINE vs LANADELUMAB-FLYO
LAMOTRIGINE vs LANREOTIDE
LAMOTRIGINE vs LANSOPRAZOLE
LAMOTRIGINE vs LANTHANUM