Does FLUOROURACIL Cause Hyperammonaemia? 263 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 263 reports of Hyperammonaemia have been filed in association with FLUOROURACIL (FLUOROURACIL). This represents 0.5% of all adverse event reports for FLUOROURACIL.
263
Reports of Hyperammonaemia with FLUOROURACIL
0.5%
of all FLUOROURACIL reports
12
Deaths
133
Hospitalizations
How Dangerous Is Hyperammonaemia From FLUOROURACIL?
Of the 263 reports, 12 (4.6%) resulted in death, 133 (50.6%) required hospitalization, and 54 (20.5%) were considered life-threatening.
Is Hyperammonaemia Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for FLUOROURACIL. However, 263 reports have been filed with the FAERS database.
What Other Side Effects Does FLUOROURACIL Cause?
Diarrhoea (5,373)
Neutropenia (4,400)
Nausea (3,757)
Vomiting (2,836)
Off label use (2,788)
Neuropathy peripheral (2,605)
Thrombocytopenia (2,426)
Fatigue (2,421)
Disease progression (2,377)
Febrile neutropenia (2,230)
What Other Drugs Cause Hyperammonaemia?
VALPROIC ACID (581)
VALPROATE (328)
DIVALPROEX (256)
LEVETIRACETAM (192)
TACROLIMUS (181)
ACETAMINOPHEN (177)
OXALIPLATIN (160)
TOPIRAMATE (156)
GLYCEROL PHENYLBUTYRATE (147)
METHOTREXATE (126)
Which FLUOROURACIL Alternatives Have Lower Hyperammonaemia Risk?
FLUOROURACIL vs FLUOROURACIL\IRINOTECAN\LEUCOVORIN
FLUOROURACIL vs FLUOROURACIL\IRINOTECAN\LEUCOVORIN\OXALIPLATIN
FLUOROURACIL vs FLUOROURACIL\LEUCOVORIN\OXALIPLATIN
FLUOROURACIL vs FLUOXETINE
FLUOROURACIL vs FLUOXETINE\FLUOXETINE