Does VALPROIC ACID Cause Hyperammonaemia? 581 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 581 reports of Hyperammonaemia have been filed in association with VALPROIC ACID (Valproic Acid). This represents 2.9% of all adverse event reports for VALPROIC ACID.
581
Reports of Hyperammonaemia with VALPROIC ACID
2.9%
of all VALPROIC ACID reports
26
Deaths
385
Hospitalizations
How Dangerous Is Hyperammonaemia From VALPROIC ACID?
Of the 581 reports, 26 (4.5%) resulted in death, 385 (66.3%) required hospitalization, and 96 (16.5%) were considered life-threatening.
Is Hyperammonaemia Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for VALPROIC ACID. However, 581 reports have been filed with the FAERS database.
What Other Side Effects Does VALPROIC ACID Cause?
Drug ineffective (3,511)
Drug interaction (1,542)
Toxicity to various agents (1,517)
Off label use (1,503)
Seizure (1,335)
Foetal exposure during pregnancy (1,046)
Somnolence (831)
Completed suicide (723)
Overdose (691)
Condition aggravated (673)
What Other Drugs Cause Hyperammonaemia?
VALPROATE (328)
FLUOROURACIL (263)
DIVALPROEX (256)
LEVETIRACETAM (192)
TACROLIMUS (181)
ACETAMINOPHEN (177)
OXALIPLATIN (160)
TOPIRAMATE (156)
GLYCEROL PHENYLBUTYRATE (147)
METHOTREXATE (126)
Which VALPROIC ACID Alternatives Have Lower Hyperammonaemia Risk?
VALPROIC ACID vs VALPROMIDE
VALPROIC ACID vs VALSARTAN
VALPROIC ACID vs VALTREX
VALPROIC ACID vs VAMOROLONE
VALPROIC ACID vs VANCOMYCIN