Does TOPIRAMATE Cause Hyperammonaemia? 156 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 156 reports of Hyperammonaemia have been filed in association with TOPIRAMATE (Topiramate). This represents 0.6% of all adverse event reports for TOPIRAMATE.
156
Reports of Hyperammonaemia with TOPIRAMATE
0.6%
of all TOPIRAMATE reports
0
Deaths
84
Hospitalizations
How Dangerous Is Hyperammonaemia From TOPIRAMATE?
Of the 156 reports, 84 (53.8%) required hospitalization, and 1 (0.6%) were considered life-threatening.
Is Hyperammonaemia Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for TOPIRAMATE. However, 156 reports have been filed with the FAERS database.
What Other Side Effects Does TOPIRAMATE Cause?
Drug ineffective (5,553)
Off label use (4,248)
Product use in unapproved indication (2,173)
Headache (1,997)
Drug intolerance (1,820)
Migraine (1,796)
Nausea (1,691)
Seizure (1,535)
Paraesthesia (1,506)
Dizziness (1,466)
What Other Drugs Cause Hyperammonaemia?
VALPROIC ACID (581)
VALPROATE (328)
FLUOROURACIL (263)
DIVALPROEX (256)
LEVETIRACETAM (192)
TACROLIMUS (181)
ACETAMINOPHEN (177)
OXALIPLATIN (160)
GLYCEROL PHENYLBUTYRATE (147)
METHOTREXATE (126)
Which TOPIRAMATE Alternatives Have Lower Hyperammonaemia Risk?
TOPIRAMATE vs TOPOTECAN
TOPIRAMATE vs TOPOTECAN\TOPOTECAN
TOPIRAMATE vs TOPROL
TOPIRAMATE vs TOREMIFENE
TOPIRAMATE vs TORIPALIMAB