Does PHENYTOIN Cause Hyperammonaemia? 95 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 95 reports of Hyperammonaemia have been filed in association with PHENYTOIN (PHENYTOIN SODIUM). This represents 0.7% of all adverse event reports for PHENYTOIN.
95
Reports of Hyperammonaemia with PHENYTOIN
0.7%
of all PHENYTOIN reports
2
Deaths
40
Hospitalizations
How Dangerous Is Hyperammonaemia From PHENYTOIN?
Of the 95 reports, 2 (2.1%) resulted in death, 40 (42.1%) required hospitalization, and 8 (8.4%) were considered life-threatening.
Is Hyperammonaemia Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for PHENYTOIN. However, 95 reports have been filed with the FAERS database.
What Other Side Effects Does PHENYTOIN Cause?
Drug ineffective (2,753)
Seizure (1,907)
Toxicity to various agents (1,248)
Drug hypersensitivity (898)
Off label use (852)
Drug interaction (772)
Drug reaction with eosinophilia and systemic symptoms (673)
Status epilepticus (544)
Fall (436)
Rash (414)
What Other Drugs Cause Hyperammonaemia?
VALPROIC ACID (581)
VALPROATE (328)
FLUOROURACIL (263)
DIVALPROEX (256)
LEVETIRACETAM (192)
TACROLIMUS (181)
ACETAMINOPHEN (177)
OXALIPLATIN (160)
TOPIRAMATE (156)
GLYCEROL PHENYLBUTYRATE (147)
Which PHENYTOIN Alternatives Have Lower Hyperammonaemia Risk?
PHENYTOIN vs PHLEUM PRATENSE POLLEN
PHENYTOIN vs PHLOROGLUCINOL
PHENYTOIN vs PHLOROGLUCINOL\1,3,5-TRIMETHOXYBENZENE
PHENYTOIN vs PHOLCODINE
PHENYTOIN vs PHOSPHORUS