Does IBRUTINIB Cause Hepatotoxicity? 67 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 67 reports of Hepatotoxicity have been filed in association with IBRUTINIB (Imbruvica). This represents 0.1% of all adverse event reports for IBRUTINIB.
67
Reports of Hepatotoxicity with IBRUTINIB
0.1%
of all IBRUTINIB reports
6
Deaths
17
Hospitalizations
How Dangerous Is Hepatotoxicity From IBRUTINIB?
Of the 67 reports, 6 (9.0%) resulted in death, 17 (25.4%) required hospitalization, and 4 (6.0%) were considered life-threatening.
Is Hepatotoxicity Listed in the Official Label?
Yes, Hepatotoxicity is listed as a known adverse reaction in the official FDA drug label for IBRUTINIB.
What Other Side Effects Does IBRUTINIB Cause?
Death (8,007)
Off label use (5,446)
Fatigue (4,479)
Diarrhoea (3,903)
Atrial fibrillation (3,671)
Pneumonia (3,015)
Incorrect dose administered (2,752)
Contusion (2,712)
Fall (2,375)
Asthenia (2,200)
What Other Drugs Cause Hepatotoxicity?
METHOTREXATE (1,917)
ACETAMINOPHEN (1,557)
LEFLUNOMIDE (829)
HYDROXYCHLOROQUINE (715)
PREDNISONE (707)
RITUXIMAB (702)
ETANERCEPT (699)
ADALIMUMAB (674)
CYCLOPHOSPHAMIDE (632)
SULFASALAZINE (613)
Which IBRUTINIB Alternatives Have Lower Hepatotoxicity Risk?
IBRUTINIB vs IBUPROFEN
IBRUTINIB vs IBUPROFEN LYSINE
IBRUTINIB vs IBUPROFEN UNKNOWN PRODUCT
IBRUTINIB vs IBUPROFEN\IBUPROFEN
IBRUTINIB vs IBUPROFEN\PHENYLEPHRINE