Does IMIPENEM Cause Hepatotoxicity? 40 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 40 reports of Hepatotoxicity have been filed in association with IMIPENEM. This represents 2.1% of all adverse event reports for IMIPENEM.
40
Reports of Hepatotoxicity with IMIPENEM
2.1%
of all IMIPENEM reports
11
Deaths
15
Hospitalizations
How Dangerous Is Hepatotoxicity From IMIPENEM?
Of the 40 reports, 11 (27.5%) resulted in death, 15 (37.5%) required hospitalization, and 13 (32.5%) were considered life-threatening.
Is Hepatotoxicity Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for IMIPENEM. However, 40 reports have been filed with the FAERS database.
What Other Side Effects Does IMIPENEM Cause?
Drug ineffective (351)
Off label use (202)
Condition aggravated (138)
Vomiting (137)
Drug resistance (117)
Nausea (111)
Dyspnoea (97)
Diarrhoea (90)
Pyrexia (90)
Product use in unapproved indication (85)
What Other Drugs Cause Hepatotoxicity?
METHOTREXATE (1,917)
ACETAMINOPHEN (1,557)
LEFLUNOMIDE (829)
HYDROXYCHLOROQUINE (715)
PREDNISONE (707)
RITUXIMAB (702)
ETANERCEPT (699)
ADALIMUMAB (674)
CYCLOPHOSPHAMIDE (632)
SULFASALAZINE (613)
Which IMIPENEM Alternatives Have Lower Hepatotoxicity Risk?
IMIPENEM vs IMIPRAMINE
IMIPENEM vs IMIQUIMOD
IMIPENEM vs IMITREX
IMIPENEM vs IMMUNE GLOBULIN NOS
IMIPENEM vs IMPLANON