Does IRINOTECAN Cause Agranulocytosis? 118 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 118 reports of Agranulocytosis have been filed in association with IRINOTECAN (Irinotecan Hydrochloride). This represents 0.4% of all adverse event reports for IRINOTECAN.
118
Reports of Agranulocytosis with IRINOTECAN
0.4%
of all IRINOTECAN reports
18
Deaths
76
Hospitalizations
How Dangerous Is Agranulocytosis From IRINOTECAN?
Of the 118 reports, 18 (15.3%) resulted in death, 76 (64.4%) required hospitalization, and 34 (28.8%) were considered life-threatening.
Is Agranulocytosis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for IRINOTECAN. However, 118 reports have been filed with the FAERS database.
What Other Side Effects Does IRINOTECAN Cause?
Diarrhoea (4,157)
Neutropenia (2,533)
Nausea (2,374)
Disease progression (2,018)
Off label use (2,018)
Vomiting (1,944)
Fatigue (1,515)
Febrile neutropenia (1,357)
Anaemia (1,231)
Thrombocytopenia (1,214)
What Other Drugs Cause Agranulocytosis?
CLOZAPINE (1,766)
CYCLOPHOSPHAMIDE (1,242)
RITUXIMAB (1,154)
SULFAMETHOXAZOLE\TRIMETHOPRIM (797)
PANTOPRAZOLE (599)
METHOTREXATE (550)
SODIUM (549)
EPIRUBICIN (491)
METAMIZOLE (438)
DOCETAXEL (436)
Which IRINOTECAN Alternatives Have Lower Agranulocytosis Risk?
IRINOTECAN vs IRON
IRINOTECAN vs IRON DEXTRAN
IRINOTECAN vs IRON ISOMALTOSIDE 1000
IRINOTECAN vs IRON POLYMALTOSE
IRINOTECAN vs IRON SUCROSE