Does METFORMIN Cause Hepatotoxicity? 192 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 192 reports of Hepatotoxicity have been filed in association with METFORMIN (Metformin Hydrochloride). This represents 0.2% of all adverse event reports for METFORMIN.
192
Reports of Hepatotoxicity with METFORMIN
0.2%
of all METFORMIN reports
87
Deaths
85
Hospitalizations
How Dangerous Is Hepatotoxicity From METFORMIN?
Of the 192 reports, 87 (45.3%) resulted in death, 85 (44.3%) required hospitalization, and 24 (12.5%) were considered life-threatening.
Is Hepatotoxicity Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METFORMIN. However, 192 reports have been filed with the FAERS database.
What Other Side Effects Does METFORMIN Cause?
Lactic acidosis (16,316)
Acute kidney injury (11,361)
Diarrhoea (7,679)
Toxicity to various agents (5,669)
Metabolic acidosis (5,236)
Hypoglycaemia (5,047)
Drug ineffective (4,991)
Nausea (4,915)
Vomiting (4,624)
Blood glucose increased (4,038)
What Other Drugs Cause Hepatotoxicity?
METHOTREXATE (1,917)
ACETAMINOPHEN (1,557)
LEFLUNOMIDE (829)
HYDROXYCHLOROQUINE (715)
PREDNISONE (707)
RITUXIMAB (702)
ETANERCEPT (699)
ADALIMUMAB (674)
CYCLOPHOSPHAMIDE (632)
SULFASALAZINE (613)
Which METFORMIN Alternatives Have Lower Hepatotoxicity Risk?
METFORMIN vs METFORMIN\PIOGLITAZONE
METFORMIN vs METFORMIN\ROSIGLITAZONE
METFORMIN vs METFORMIN\SAXAGLIPTIN
METFORMIN vs METFORMIN\SITAGLIPTIN
METFORMIN vs METFORMIN\VILDAGLIPTIN